Hollow granular medicine and its preparation

Details Hollow granular medicine and its preparation Hollow granular medicine and its preparation

1989-06-19

1991-10-15

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424 78, 424469, A61K 916

Patent

active

050573233

ABSTRACT:
A granular medicine with slow drug-release characteristics that is sufficiently absorbed in the intestines, in which the granular medicine has a hollow spherical structure, a drug is dispersed in the shell, which mainly consists of an enteron-soluble polymer. The method for preparing the medicine includes the steps of: (a) mixing a hydrophilic or hydrophobic drug with an enteron-soluble polymer in a mixture of an aliphatic alcohol and a chlorohydrocarbon; and (b) pouring this mixture into water or an aqueous medium, and stirring the solution to precipitate the medicine.

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patent: 4834985 (1989-05-01), Elger et al.
patent: 4844905 (1989-07-01), Ichikawa et al.
Yasuo Nozawa and Fukuji Higashide, Kobunshi Ronbunshu, Nov. 1977, vol. 34, No. 11, 757-762, "Hole Formation in the Membrane of Polystyrene Microcapsules".

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