Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Particulate form
Patent
1990-09-20
1992-02-11
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Particulate form
424408, 424451, 424468, 424470, 424484, 424489, A61K 916
Patent
active
050874551
ABSTRACT:
A granular medicine with slow drug-release characteristics that is sufficiently absorbed in the intestines, in which the granular medicine has a hollow spherical structure, a drug is dispersed in the shell, which mainly consists of an enteron-soluble polymer. The method for preparing the medicine includes the steps of: (a) mixing a hydrophilic or hydrophobic drug with an enteron-soluble polymer in a mixture of an aliphatic alcohol and a chlorohydrocarbon; and (b) pouring this mixture into water or an aqueous medium, and stirring the solution to precipitate the medicine.
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Yasuo Nozawa and Fukuji Higashide, Kobunshi Ronbunshu, Nov. 1977, vol. 34, No. 11, 757-762, "Hole Formation in the Membrane of Polystyrene Microcapsules".
Ito Yoji
Kawashima Yoshiaki
Niwa Toshiyuki
Takeuchi Hirofumi
Benston, Jr. William E.
Page Thurman K.
Showa Yakuhin Kako Co. Ltd.
Yoshiaki Kawashima
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