Chemistry: molecular biology and microbiology – Apparatus – Bioreactor
Patent
1997-05-22
1999-09-21
Beisner, William H.
Chemistry: molecular biology and microbiology
Apparatus
Bioreactor
435370, 435400, 604 4, 21032181, C12M 306
Patent
active
059553537
ABSTRACT:
A bioreactor containing living animal cells at a density approaching that of normal animal tissue is described. High cell loading is achieved by providing a flow restrictor which controls fluid flow through the bioreactor during cell loading. Methods for making and using the bioreactor are also described.
REFERENCES:
patent: 3734851 (1973-05-01), Matsumura
patent: 3883393 (1975-05-01), Knazek et al.
patent: 4220725 (1980-09-01), Knazek et al.
patent: 4241187 (1980-12-01), White
patent: 4293413 (1981-10-01), Schnell
patent: 4488911 (1984-12-01), Luck et al.
patent: 4514499 (1985-04-01), Noll
patent: 4537860 (1985-08-01), Tolbert et al.
patent: 4559304 (1985-12-01), Kasai et al.
patent: 4647539 (1987-03-01), Bach
patent: 4675002 (1987-06-01), Viles et al.
patent: 4692411 (1987-09-01), Ghose
patent: 4720462 (1988-01-01), Rosenson
patent: 4804628 (1989-02-01), Cracauer et al.
patent: 4833083 (1989-05-01), Saxena
patent: 4837379 (1989-06-01), Weinberg
patent: 4861485 (1989-08-01), Fecondini
patent: 4873033 (1989-10-01), Heckmann et al.
patent: 4923598 (1990-05-01), Schul
patent: 4959148 (1990-09-01), Clark, III
patent: 4999298 (1991-03-01), Wolfe et al.
patent: 5013437 (1991-05-01), Trimmer et al.
patent: 5015585 (1991-05-01), Robinson
patent: 5043260 (1991-08-01), Jauregui
patent: 5064764 (1991-11-01), Besnainon et al.
patent: 5106743 (1992-04-01), Franzblau et al.
patent: 5108923 (1992-04-01), Benedict et al.
patent: 5108926 (1992-04-01), Klebe
patent: 5116493 (1992-05-01), Chick et al.
patent: 5198110 (1993-03-01), Hanai et al.
patent: 5211849 (1993-05-01), Kitaevich et al.
patent: 5213720 (1993-05-01), Civerchia
patent: 5240614 (1993-08-01), Ofsthun et al.
patent: 5254249 (1993-10-01), Terada et al.
patent: 5254471 (1993-10-01), Mori et al.
patent: 5270192 (1993-12-01), Li et al.
patent: 5290684 (1994-03-01), Kelly
patent: 5368555 (1994-11-01), Sussman et al.
patent: 5376548 (1994-12-01), Matsuo et al.
patent: 5411662 (1995-05-01), Nicolas, Jr. et al.
patent: 5480552 (1996-01-01), Soltys et al.
patent: 5510254 (1996-04-01), Naughton et al.
patent: 5510257 (1996-04-01), Sirkar et al.
patent: 5512474 (1996-04-01), Clapper et al.
patent: 5516691 (1996-05-01), Gerlach
patent: 5527467 (1996-06-01), Ofsthun et al.
patent: 5536656 (1996-07-01), Kemp et al.
patent: 5595909 (1997-01-01), Hu et al.
patent: 5605835 (1997-02-01), Hu et al.
patent: 5643794 (1997-07-01), Liu et al.
patent: 5658797 (1997-08-01), Bader
patent: 5700372 (1997-12-01), Takesawa et al.
patent: 5730712 (1998-03-01), Falkvall et al.
Akimoto et al., "Fundamental Studies on Biological Artificial Liver Support; Liver Functions of Entrapped Hepatocytes," Jpn. J. Artif. Organs, 14(1):249-252 (1985).
Anderson et al., "Cell-Mediated Contraction of Collagen Lattices in Serum-Free Medium: Effect of Serum and Nonserum Factors," In Vitro Cell Dev. Biol., 26:61-66 (Jan. 1990).
Bell et al., "Production of a Tissue-like Structure by Contraction of Collagen Lattices by Human Fibroblasts of Different Proliferative Potential In Vitro," Proc. Natl. Acad. Sci. USA, 76(3):1274-1278 (Mar. 1979).
Block et al., "D-Galactosamine-Induced Liver Injury in Large Dogs: is it really Fulminant Liver Failure?," Submitted Abstract to Oct. 1996 AASLD Meeting.
Block et al., "Preclinical Evaluation of a Novel Extracorporeal Bioartificial Liver Device (BAL)," Submitted Abstract to Oct. 1996 AASLD Meeting.
Catapano, "Mass Transfer Limitations to the Performance of Membrane Bioartificial Liver Support Devices," The International Journal of Artificial Organs, 19(1):18-35 (1996).
Chari et al., "Brief Report: Treatment of Hepatic Failure with Ex Vivo Pig-Liver Perfusion Followed by Liver Transplantation," The New England Journal of Medicine, 331(4):234-269 (Jul. 28, 1994).
Demetriou et al., "Early Clinical Experience with a Hybrid Bioartificial Liver," Artificial Liver Support, Scand. J. Gastroenterol. Suppl., 208(1):111-117 (1995).
Demetriou et al., "New Method of Hepatocyte Transplantation and Extracorporeal Liver Support," Ann. Surg., 204(3):259-271 (Sep. 1986).
Dixit, "Development of a Bioartificial Liver Using Isolated Hepatocytes," Artificial Organs, 18(5):371-384 (1994).
Dixit, "Transplantation of Isolated Hepatocytes and Their Role in Extrahepatic Life Support Systems," Scand J. Gastroenterol, 30 Suppl. 208:101-110 (1995).
Eiseman et al., "Hepatocyte Perfusion Within Centrifuge," Surgery, Gynecology & Obstetrics, 142:21-28 (Jan. 1976).
Fernandez-Bueno, "Development of an Extracorporeal Liver Support System: Initial Results," Military Medicine, 157(4):180-182 (Apr. 1992).
Fuchs, "Amino Acid Metabolism by Hepatocytes in a Hybrid Liver Support Bioreactor," The International Journal of Artificial Organs, 17(12):663-669 (1994).
Gerlach et al., "Bioreactor for a Larger Scale Hepatocyte in Vitro Perfusion," Transplantation, 58(9):984-988 (Nov. 15, 1994).
Gerlach et al., "Gas Supply Across Membranes in Bioreactors for Hepatocyte Culture," Artificial Organs, 14(5):328-333 (1990).
Gerlach et al., "Hybrid Liver Support System in a Short Term Application on Hepatectomized Pigs," The International Journal of Artificial Organs, 17(10):549-553 (1994).
Guidry et al., "Studies on the Mechanism of Hydrafted Collagen Gel Reorganization by Human Skin Fibroblasts," J. Cell. Sci., 79:67-81 (1985).
Hu et al., "Cultivation of Hepatocytes in a New Entrapment Reactor: a Potential Bioartificial Liver," Animal Cell Culture and Production of Biologicals, 75-80 (1991).
Hu et al., "Enhancement of Cytochrome P450 Function of Collagen Entrapped Hepatocytes by the Addition of Liver Extracellular Matrix Components," Cell Transplant Society, Second International Congress, Minneapolis, May 1994.
Jauregui, "Treatment of Hepatic Insufficiency Based on Cellular Therapies," The International Journal of Artificial Organs, 14(6):321-326 (1991).
Jauregui et al., "Use of Mammalian Liver Cells for Artificial Liver Support," Cell Transplantation, 5(3):353-367 (1996).
Koshino et al., "A Biological Extracorporeal Metabolic Device for Hepatic Support," Trans. Amer. Soc. Artif. Int. Organs, 20:492-500 (1975).
LePage et al., "A Bioartificial Liver Used as a Bridge to Liver Transplantation in a 10-Year-Old Boy," American Journal of Critical Care, 3(3):224-227 (May 1994).
LePage et al., "Plasma Separation for Artificial Liver Support," Journal of Clinical Apheresis, 10:70-75 (1995).
Li et al., "Culturing of Primary Hepatocytes as Entrapped Aggregates in a Packed Bed Bioreactor: A Potential Bioartificial Liver," In Vitro Cell. Dev. Biol., 29A:249-254 (Mar. 1993).
Lie et al., "Successful Treatment of Hepatic Coma by a New Artificial Liver Device in the Pig," Res. Exp. Med., 185:483-494 (1985).
Matthew et al., "Microencapsulated Hepatocytes," Trans. Am. Soc. Artif. Intern. Organs, 37:M328-M330 (1991).
Matthew et al., "Performance of Plasma-Perfused, Microencapsulated Hepatocytes: Prospects for Extracorporeal Liver Support," Journal of Pediatric Surgery, 28(11):1423-1428 (Nov. 1993).
McGuire et al., "Review of Support Systems Used in the Management of Fulminant Hepatic Failure," Dig. Dis., 13:379-388 (1995).
Mito, "Hepatic Assist: Present and Future," Artificial Organs, 10(3):214-218 (1986).
Miura et al., "Characterization of Immobilized Hepatocytes as Liver Support," Biomat., Art. Cells, Art. Org., 18(4):549-554 (1990).
Miura et al., "Synthesis and Secretion of Protein by Hepatocytes Entrapped within Calcium Alginate," Artificial Organs, 10(6):460-465 (Dec. 1986).
Miyoshi et al., "Long-Term Continuous Culture of Hepatocytes in a Packed-Bed Reactor Utilizing Porous Resin," Biotechnology and Bioengineering, 43:635-644 (1994).
Morsiani et al., "Automated Liver Cell Processing Facilitates Large Scale Isolation and Purification of Porcine Hepatocytes," ASAIO Journal, 41(2):155-161 (Apr.-Jun. 1995).
Neuzil et al., "Use of a Novel Bioartificial Liver in a Patient with Acute Liver Insufficiency," Surgery, 113(3):340-343 (Mar. 1993).
Nyberg et al., "Bilirubin Conjugation in a Three Compartment Hollow Fiber Bioreactor," Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 12(1):0
Beisner William H.
Excorp Medical, Inc.
LandOfFree
Hollow fiber bioreactor with an extrafilament flow plug does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Hollow fiber bioreactor with an extrafilament flow plug, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Hollow fiber bioreactor with an extrafilament flow plug will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-79682