HNF3.delta. compositions

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

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435243, 4353201, 435325, 435410, 536 231, 536 235, C12P 2106, C12N 100, C12N 510, C12N 1512, C12N 1563

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058612785

ABSTRACT:
Purified HNF3.delta. proteins and processes for producing them are disclosed. DNA molecules encoding the HNF3.delta. proteins are also disclosed. The proteins may be used in regulating the transcription of one or more genes involved in the formation, differentiation, proliferation and maintenance of cells which form organ tissues, particularly pancreatic cells, as well as other tissue repair.

REFERENCES:
Weigel et al., Cell 57:645-658 (1989).
Weigel and Jackle, Cell 63:455-456 (1990).
Costa, Liver and Gene Expression (Tronche and Yaniv, eds.), pp. 183-204 (R. G. Landes Company) (1994).
Lai et al., PNAS USA 90:10421-10423 (1993).
Kaufman et al., Nucl. Acids Res 19:4485-4490 (1991).
Ngo et al., The Protein Folding Problem and Tertiary Structure Prediction, Mertz et al (eds.), pp. 433 and 492-495, Birkhauser, Boston 1994.
Westendorf et al., PNAS USA, vol. 91, pp. 714-718, Jan. 1994.

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