HN epitope recognized by avian immune system and antigenic...

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Virus or component thereof

Reexamination Certificate

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C424S186100, C530S327000, C435S235100

Reexamination Certificate

active

08029801

ABSTRACT:
The present invention relates to an epitope of HN protein in Newcastle disease virus which can be recognized by an avian immune system and an antibody against the epitope, a method for detecting a Newcastle disease virus by using the antibody, and an antigenic variant of Newcastle disease virus carrying changes in the epitope. The epitope of HN protein and the antigenic variant of Newcastle disease virus can be used for developing efficient vaccines, and further, in diagnosing the Newcastle disease virus rapidly and exactly.

REFERENCES:
Gotoh et al (Virology 163:174-182, 1988).
Sakaguchi et al (Virology 169:260-272, 1989).
Nishikawa, K. et al. “Monoclonal antibodies as functional probes of the HN glycoprotein of Newcastle disease virus. Biological characterization and use for strain comparisons” Virology, Oct. 30, 1983, vol. 130, No. 2, pp. 318-330.
Cormam, J.J., et al. “Characterization of the sites of proteolytic activation of Newcastle disease virus membrane glycoprotein precursors” L Biol Chem., Sep. 5, 1988, vol. 263, No. 25, pp. 12522-12531.
NCBI Accession No. AAY56377 and AAY56378 (Jan. 1, 2005).
Cho, Sun-Hee et al., “Characterization of New Castle Virus type VII having HN antigenic variant of linear epitope”, The 49th annual Meeting of the Korean Society of Veterinary Science, Korean Socienty of Verterinary Science Coperation, Sep. 23, 2005.

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