Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1999-02-26
2000-11-21
Priebe, Scott D.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
536 234, 536 235, 536 2431, 536 2433, 4353201, 435325, 4352523, 436503, C12Q 168, C12N 1500, C12N 500, C12N 120, C07H 2104
Patent
active
061501107
ABSTRACT:
An oncogene designated HMGI(Y)-LAMA4* incorporates a HMGI(Y) domain fused through inversion and translocation to LAMA4*, a novel gene transcript with a epidermal-growth-factor-like/zinc-finger-like motif. Molecular characterization of HMGI(Y)-LAMA4* provides nucleic acid sequences and amino acid sequences useful for detection and treatment of certain tumors.
REFERENCES:
Verma et al. Nature 389: 239-242, especially p. 239, Sep. 1997.
Anderson et al. Nature 392: 25-30, especially pp. 25 and 30, Apr. 1997.
Crook In Basic Principles of Antisense Therapeutics, Springer-Verlag, Eds, New York, pp. 1-4, Jul. 1998.
Branch. Trends in Biochemical Sciences 23: 45-50, (see abstract; p. 49, paragraph bridging coluns 1 and 2; and p. 49, col. two first full paragraph), Sep. 1997.
Xiao et al. American Journal of Pathology 150(3): 901-910, (see p. 907, first sentence of first full paragraph; and p. 907, col. 2, first full paragraph; and p. 901, col. 2, first sentence of first full paragraph), Mar. 1997.
Wall. Theriogenology, 45: 57-68 See especially p. 61, last paragraph and p. 62, first paragraph, 1996.
Houdebine (Journal of Biotechnology 34:269-287, se especially p. 275, col. 1, 1st paragraph), 1994.
Mullins et al. (Journal of Clinical Investigation 98(11): S37-S40 See especially p. S39, 1996.
Kappel et al. (Current Opinion in Biotechnology, 3: 548-553, especially p. 549, col. 2, 3rd full paragraph, 1992.
Iivanainen et al (FEBS Lett. 365(2-3): 183-188, 1995 See Abstract and Figure 2, May 1995.
Xiao et al., "HBGI(Y) Activation by Chromosome 6p21 Rearrangements in Multilineage Mesenchymal Cells from Pulmonary Hamartoma," (1997) American Journal of Pathology, vol. 150, pp. 901-910.
Fletcher Jonathan
Xiao Sheng
Priebe Scott D.
Schnizer Richard
The Brigham and Women's Hospital, Inc.
LandOfFree
HMGI(Y)-LAMA4* fusion oncogene, oncoprotein and methods of use does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with HMGI(Y)-LAMA4* fusion oncogene, oncoprotein and methods of use, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and HMGI(Y)-LAMA4* fusion oncogene, oncoprotein and methods of use will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1255330