HMGCR isoforms in prediction of efficacy and identification...

Details HMGCR isoforms in prediction of efficacy and identification... HMGCR isoforms in prediction of efficacy and identification...

2006-07-21

2011-12-27

Martinell, James (Department: 1634)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C435S006130, C435S006180, C435S007100

Reexamination Certificate

active

08084209

ABSTRACT:
The present invention provides methods for assessing a subject's responsiveness to a HMGCR inhibitor therapy, and selection of a HMGCR inhibitor therapy based upon such methods. The invention further provides methods for identifying agents that modulate HMGCR activity, e.g., through modulating HMGCR mRNA splicing, while avoiding elevation of the statin-resistant isoform of HMGCR.

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patent: WO03102209 (2003-12-01), None
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Keller, G., et al. 3-Hydroxy-3-methylglutaryl coenzyme A reductase localization in rat liver peroxisomes and microsomes of control and cholestyramine-treated animals: quantitative biochemical and immunoelectron microscopical analyses. J Cell Biol. 1986, vol. 103, No. 3, pp. 875-886.

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