HMG-CoA reductase inhibitors produced by Nocardia sp. (MA 6455)

Details HMG-CoA reductase inhibitors produced by Nocardia sp. (MA 6455) HMG-CoA reductase inhibitors produced by Nocardia sp. (MA 6455)

1988-04-14

1991-03-05

Schwartz, Richard A.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing heterocyclic carbon compound having only o, n, s,...

435155, 435 58, 435872, 4352532, 435135, 435146, 435148, C12P 1706, C12P 702, C12P 3306, C12N 120

Patent

active

049977555

ABSTRACT:
A microbiological process is described for the preparation of 6-desmethyl-6-.beta.-hydroxymethyl and 6-desmethyl-6-.beta.-carboxylovastatin derivatives and 8-acyl analogs thereof.

REFERENCES:
patent: 4444784 (1984-04-01), Hoffman et al.
patent: 4448979 (1984-05-01), Terahara et al.
patent: 4517373 (1985-05-01), Terahara et al.
patent: 4537859 (1985-08-01), Terahara et al.
Lee, S. S., and Sih, C. J. 1967, "Mechanism of Steroid Oxidation by Microorganisms," Biochemistry vol. 6, pp. 1395-1403.
Raymond, R. L., et al. 1967, "Microbial Hydrocarbon Co-Oxidation," Applied Microbiology, vol. 15, pp. 857-865.

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