HMG-CoA reductase inhibitors and method

Details HMG-CoA reductase inhibitors and method HMG-CoA reductase inhibitors and method

2004-11-15

2008-09-02

Seaman, D. Margaret (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C546S113000, C514S312000

Reexamination Certificate

active

07420059

ABSTRACT:
Compounds are provided having the following structureand pharmaceutically acceptable salts thereof,wherein R1, R2, R3, R4, U, V, W, Y, and n are as defined above,which compounds are HMG CoA reductase inhibitors and thus are active in inhibiting cholesterol biosynthesis, modulating blood serum lipids, for example, lowering LDL cholesterol and/or increasing HDL cholesterol, and treating hyperlipidemia, dyslipidemia, hypercholesterolemia, hypertriglyceridemia and atherosclerosis as well as Alzheimer's disease and osteoporosis and may be employed as hormone replacement therapy.A method for treating the above diseases employing the above compounds is also provided.

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