Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1989-03-27
1990-02-13
Raymond, Richard L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514460, 514824, 549292, A61K 31365, C07D30930
Patent
active
049007548
ABSTRACT:
Disclosed are novel 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors useful as antihypercholesterolemic agents represented by the formula ##STR1## and the corresponding ring-opened hydroxy acids derived therefrom and pharmaceutically acceptable salts thereof.
Pharmaceutical compositions containing said compounds and method of inhibiting the biosynthesis of cholesterol therewith are also disclosed.
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Neuenschwander Kent W.
Regan John R.
Balogh Imre (Jim)
Nicholson James A.
Raymond Richard L.
Rorer Pharmaceutical Corp.
Russell M. W.
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