Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...
Patent
1989-12-14
1991-02-19
Raymond, Richard L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Radical -xh acid, or anhydride, acid halide or salt thereof...
562466, 562434, 562437, 562438, 562452, 562455, 562427, 514559, 514562, 514563, 514564, 514567, 514824, A61K 3119, C07C 6222, C07C 6232
Patent
active
049944940
ABSTRACT:
Disclosed are novel 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors useful as antihypercholesterolemic agents represented by the formula ##STR1## and the corresponding ring-opened hydroxy acids derived therefrom and pharmaceutically acceptable salts thereof.
Pharmaceutical compositions containing said compounds and method of inhibiting the biosynthesis of cholesterol therewith are also disclosed.
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patent: 4375475 (1983-03-01), Willard et al.
patent: 4567289 (1986-01-01), Willard et al.
patent: 4611067 (1986-09-01), Volante et al.
patent: 4622338 (1986-11-01), Baron et al.
patent: 4668699 (1987-05-01), Hoffman et al.
Bruno Joseph G.
Kuhla Donald E.
Neuenschwander Kent W.
Regan John R.
Balogh Imre (Jim)
Nicholson James A.
Raymond Richard L.
Rhone-Poulenc Rorer Pharmaceuticals Inc.
Russell Mark W.
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