HLA-DRBI peptides with specific binding affinity for HLA-DQ mole

Details HLA-DRBI peptides with specific binding affinity for HLA-DQ mole HLA-DRBI peptides with specific binding affinity for HLA-DQ mole

1995-08-31

1999-10-12

Chambers, Jasemine C.

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

435 72, 4353201, 4351723, 424 91, 424 9321, C12N 1563, C12N 510, C12N 1509

Patent

active

059657871

ABSTRACT:
Disclosed are transgenic mice carrying a human HLA-DQ sgene. The transgenic mice are deficient in mouse H-2 class II molecules. Such mice provide animal model systems to identify peptides useful for preventing or treating rheumatoid arthritis. Also disclosed are methods and materials for treating rheumatoid arthritis, including administration of peptides having specific binding affinity for HLA-DQ molecules expressed in a rheumatoid arthritis patient.

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