HIV trans-activator Tat binding to CDK7 and activation of CTD ph

Details HIV trans-activator Tat binding to CDK7 and activation of CTD ph HIV trans-activator Tat binding to CDK7 and activation of CTD ph

1997-10-03

1999-11-30

Stucker, Jeffrey

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving virus or bacteriophage

530326, 435 72, C12Q 170, A61K 3800, G01N 33567, G01N 3353

Patent

active

059940557

ABSTRACT:
The present invention relates to methods of inhibiting Tat trans-activation in a cell and methods of assaying for inhibitors of Tat trans-activation.

REFERENCES:
patent: 5733920 (1998-03-01), Mansuri et al.
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Parada et al., Enhanced processivity of RNA polymerase II triggered by Tat-induced phosphorylation of its carboxy-terminal domain, Nature384:375-378 (1996).
Cujec et al., The Human Immunodeficiency Virus Transactivator Tat Interacts with the RNA Polymerase II Holoenzyme, Mollecular and Cellular Biology, 27:(4)1817-1823 (1977).
Feaver et al., CTD Kinase Associated with Yeast RNA Polymerase II Initiation Factor b, Cell Press, 67:1223-1230 (1991).
Feaver et al., Relationship of CDK-Activating Kinase and RNA Polymerase II CTD Kinase TfIIH/TFIIK, Cell Press, 79:1103-1109 (1994).
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Chun et al., Requirements for RNA Polymerase II Carboxyl-terminal Domain for Activated Transcription of Human Retroviruses Human T-Cell Lymphotropic Virus I and HIV-1, The Journal of Biochemical Chemistry, 271(44)27888-27894 (1996).
Okamoto, et al., Transactivation by human immunodeficiency virus Tat protein requires the C-terminal domain of RNA polymerase II, Proc. Natl. Acad. Sci., 93:11575-11579 (1996).
Yang, et al., The Human Immunodeficiency Virus Tat Proteins Specifically Associate with TAK in Vivo and Require the Carboxyl-Terminal Domain of RNA Polymerase II for Function, Journal of Virology 70(7):4576-4584 (1996).
Fisher et al., A Novel Cyclin Associates with MO15/CDK7 to form the CDK-Activating Kinase, Cell Press, 78:713-714, (1994).
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Makela et al., A cyclin associated with the CDK-activating kinase MO15, Nature 371:254-257 (1994).
Maldonado et al., A Human RNA polymerase II complex asociated with SRB an DNA-repair proteins, Nature 381:86-89 (1996).

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