HIV trans-activator TAT binding to CDK7 and activation of CTD ph

Details HIV trans-activator TAT binding to CDK7 and activation of CTD ph HIV trans-activator TAT binding to CDK7 and activation of CTD ph

1999-10-18

2000-12-12

Park, Hankyel T.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving virus or bacteriophage

435 72, 530326, C12Q 170, G01N 3353, A61K 3800

Patent

active

061596841

ABSTRACT:
The present invention relates to methods of inhibiting Tat trans-activation in a cell and methods of assaying for inhibitors of Tat trans-activation.

REFERENCES:
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Cujec et al., The Human Immunodeficiency Virus Transactivator Tat Interacts with the RNA Polymerase II Holoenzyme, Mollecular and Cellular Biology, 27: (4)1817-1823 (1977).
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Makela et al., A cyclin associated with the CDK-activating kinase MO15, Nature 371:254-257 (1994).
Maldonado et al., A Human RNA polymerase II complex associated with SRB and DNA-repair proteins, Nature 381:86-89 (1996).

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