Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Primate cell – per se
Patent
1994-07-07
1997-12-02
LeGuyader, John L.
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Primate cell, per se
435 6, 435 9131, 4351723, 435325, 435366, 536 231, 536 232, 536 245, C12N 1583, C12Q 168
Patent
active
056935358
ABSTRACT:
An enzymatic nucleic acid molecule which cleaves an immunodeficiency virus RNA in a gene required for viral replication, e.g., the nef or tat gene regions.
REFERENCES:
patent: 4987071 (1991-01-01), Cech et al.
patent: 5144019 (1992-09-01), Rossi et al.
patent: 5149796 (1992-09-01), Rossi et al.
patent: 5168053 (1992-12-01), Altman et al.
patent: 5527895 (1996-06-01), Hampel et al.
Slim et al. Nucleic Acids Research Symposium Series No. 24 (1991) England pp. 55-58.
Ratner et al. Nature 313:277 (1985).
Barinaga Science 262:1512 (1993).
Stull et al. Pharm. Res. 12:466 (1995).
Johshen et al. Science 260:1286 (1993).
Bartel et al., "HIV-1 Rev Regulation Involves Recognition of Non-Watson-Crick Base Pairs in Viral RNA," Cell 67:529 (1991).
Braun et al., "In Vitro Cleavage of HIV-1 vif RNA By a Synthetic Ribozyme," Virus Genes 5:17 (1991) (Abstract).
Beckett and Uhlenbeck, in Oligonucleotide Synthesis: A Practical Approach, Ch. 8 "Enzymatic Synthesis of Oligoribonucleotides," M.J. Gait, Ed., 1984 IRL Press, Ltd.
Block et al., "Innovations in Antiviral Development and the Detection of Virus Infection," Plenum Press, New York pp. 125-128 (1992).
Cameron et al., "Specific Gene Expression by Engineered Ribozymes in Monkey Cells," Proc. Natl. Acad. Sci. USA 86:9139-9143 (1989).
Cech, "Ribozymes and Their Medical Implications," JAMA 260:3030 (1988).
Chang et al., "Ribozyme-Mediated Site-Specific Cleavage of the HIV-1 Genome" Clinical Biotechnology 2:23 (1990).
Chen et al., "Multitarget-Ribozyme Directed to Cleave at up to Nine Highly Conserved HIV-1 env RNA Regions Inhibits HIV-1 Replication-Potential Effectiveness Against Most Presently Sequenced HIV-1 Isolates," Nucleic Acids Research 20:4581-4589 (1992).
Cheng-Mayer et al., "Differential Effects of nef on HIV Replication: Implications for Viral Pathogenesis in the Host," Science 246:1629 (1989).
Crisell et al., "Inhibition of HIV-1 Replication by Ribozymes That Show Poor Activity in vitro," Nucleic Acids Research 21:5251-5255 (1993).
Dropulic et al., "Functional Characterization of a U5 Ribozyme: Intracellular Suppression of Human Immunodeficiency Virus Type I Expression," Journal of Virology 66:1432-1441 (1992).
Gallo et al., Cancer Res. 43:3892 (1983).
Guatelli et al., J. Cell Biochem. 16E:79 (1992).
Guerrier-Takada et al., "The RNA Moiety of Ribonuclease P Is the Catalytic Subunit of the Enzyme", Cell 35:849 (1983).
Hampel et al., "RNA Catalyst for Cleaving Specific RNA Sequences," filed Sep. 20, 1989, which is a Continuation-in-Part of U.S. Serial No. 07/247,100 filed Sep. 20, 1988.
Hampel et al., "`Hairpin` Catalytic RNA Model: Evidence for Helices and Sequence Requirement for Substrate RNA", Nucleic Acids Research 18:299 (1990).
Hampel and Tritz, "RNA Catalytic Properties of the Minimum (-)s TRSV Sequence," Biochemistry 28:4929 (1989).
Hsaeloff and Gerlach, "Simple RNA Enzymes with New and Highly Specific Endoribonuclease Activities," Nature 334:585 (1988).
Heidenreich and Eckstein, "Hammerhead Ribozyme-mediated Cleavage of the Long Terminal Repeat RNA of Human Immunodeficiency Virus Type 1," Journal of Biological Chemistry 267:1904-1909 (1992).
Herschlag and Cech, "Catalysis of RNA Cleavage by the Tetrahymena thermophila Ribozyme 1. Kinetic Description of the Reaction of the RNA Substrate Complementary to the Active Site," Biochemistry 29:10159-10171 (1990).
Jeang and Berkhout, "Kinetics of HIV-1 Long Terminal Repeat trans-Activation," J. Biol. Chem. 267:17891 (1992).
Jeffries and Symons, "A Catalytic 13-mer Ribozyme," Nucleic Acids Research 17:1371-1377 (1989).
Joseph and Burke, "Optimization of an Anti-HIV Hairpin Ribozyme by in Vitro Selection," J. Biol. Chem. 268:24515-24518 (1993).
Kim and Cech, "Three-dimensional model of the active site of the self-splicing rRNA precursor of Tetrahymena," Proc. Natl. Acad. Sci. USA 84:8788 (1987).
Lingelbach et al., "An Extended RNA/RNA Duplex Structure Within the Coding Region of mRNA Does Not Block Translational Elongation," Nucleic Acids Research 16:3405-3414 (1988).
Lorentzen et al., "In Vitro Cleavage of HIV-1 vif RNA by a Synthetic Ribozyme," Virus Genes 5:17 (1991).
Le Guern et al., "Human Immunodeficiency Virus (HIV) Type 1 Can Superinfect HIV-2-infected Cells: Pseudotype Virions Produced with Expanded Cellular Host Range," Proc. Natl. Acad. Sci. USA 89:363 (1992).
Malim et al., "Functional Comparison of the Rev Trans-activators Encoded by Different Primate Immunodeficiency Virus Species" Proc. Natl. Acad. Sci. USA 86:8222 (1989).
Mamone et al., "Design of Mannerhead Ribozymes Targeted to Sequences in HIV, HSV, and the RAT ANF GENE," Abstract of Keystone, CO (May 27, 1992).
Matsukura et al., "Regulation of Viral Expression of Human Immunodeficiency Virus in vitro by an Antisense Phosphorothioate Oligodeoxynucleotide Against rev (art/trs) in Chronically Infected Cells," Proc. Natl. Acad. Sci. USA 86:4244 (1989).
Ojwang et al., "Inhibition Of Human Immunodeficiency Virus Type 1 Expression By A Hairpin Ribozyme", Proc. Natl. Acad. Sci. USA 89:10802-10806 (1992).
Pavco et al., "Regulation of Self-Splicing Reactions by Antisense RNA," Abstract of Keystone, CO (May 27, 1992).
"The Papovaviridae", Ed. Salzman et al., vol. 2, The Viruses, Plenum Press, NY 1987.
Perrotta and Been, "Cleavage of Oligoribonucleotides by a Ribozyme Derived from the Hepatitis .delta. Virus RNA Sequence," Biochemistry 31:16 (1992).
Rossi et al., "Ribozymes As Therapies For AIDS", Annals for the New York Academy of Sciences 606:184-200 (1990).
Rossi et al., J. Cell Biochem. 14A:D428 (1990).
Rossi et al., "Ribozymes as Anti-HIV-1 Therapeutic Agents: Principles, Applications, and Problems," Aids Research and Human Retroviruses 8:183 (1992).
Sambrook et al., Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Laboratory Press, New York, pp. 7.71-7.78 (1989).
Sarver et al., "Ribozymes as Potential Anti-HIV-1 Therapeutic Agents" Science 247:1222 (1990).
Scanlon et al., "Ribozyme-Mediated Cleavage of c-fos mRNA Reduces Gene Expression of DNA Synthesis Enzymes and Metallothionein," Proc. Natl. Acad. Sci. USA 88:10591-10595 (1991).
Sioud and Drlica, "Prevention of Human Immunodeficiency Virus Type 1 Integrase Expression in Escherichia coli by a Ribozyme" Proc. Natl. Acad. Sci. USA 88:7303 (1991).
Slim et al., "Configurationally Defined Phosphorothioate-Containing Oligoribonucleotides in the Study of the Mechanism of Cleavage of Hammerhead Ribozymes," Nucleic Acids Research 19:1183-1188 (1991).
Taylor and Rossi, "Ribozyme-Mediated Cleavage of an HIV-1 gag RNA: The Effects of Nontargeted Sequences and Secondary Structure on Ribozyme Cleavage Activity," Antisense Res. and Dev. 1:173-186 (1991).
Terwilliger et al., "Allelic Variation in the Effects of the nef gene on Replication of Human Immunodeficiency Virus Type 1" Proc. Natl. Acad. Sci. USA 88:10971 (1991).
Tsukiyama-Kohara et al., "Internal Ribosome Entry Site Within Hepatits C Virus RNA," Journal of Virology 66:1476 (1992).
Usman et al., "Automated Chemical Synthesis of Long Oligoribonucleotides Using 2'-O-Silylated Ribonucleoside 3'-O-Phosphoramidtes on a Controlled-Pore Glass Support: Synthesis of a 43-Nucleotide Sequence Similar to the 3'-Half Molecule of an Escherichia coli Formylmethoionine tRNA," J. Am. Chem. Soc. 109:7845-7854 (1987).
Viscidi et al., "Inhibition of Antigen-Induced Lymphocyte Proliferation by Tat Protein from HIV-1" Science 246:1606 (1989).
von Weizsacker, et al., "Cleavage of hepatitis B virus RNA by three ribozymes transcribed from a single DNA template," Biochemical and Biophysical Research Communications 189:743-748 (Dec. 15, 1992).
Weerasinghe et al., "Resistance to Human Immunodeficiency Virus Type 1 (HIV-1) Infection in Human CD4.sup.+ Lymphocyte-Derived Cell Lines Conferred by using Retroviral Vectors Expressing an HIV-1 RNA-Specific Ribozyme," Journal of Virology 65:5531 (1991).
Xing et al., "Ribozymes Which Cleave Arenavirus RNAs: Identification of Suceptible Target Sites and Inhibition by Target Site Secondary Structure" Journal of Virology 66:1361-1369 (1992).
Yu et al., "A Hairpin Ribozyme Inhibits Expression of Diverse Strain
Chowrira Bharat
Draper Kenneth G.
McSwiggen James
Stinchcomb Dan T.
Thompson James D.
LeGuyader John L.
Ribozyme Pharmaceuticals Inc.
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