HIV targeted hairpin ribozymes

Details HIV targeted hairpin ribozymes HIV targeted hairpin ribozymes

1995-06-07

1999-02-09

LeGuyader, John L.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Method of regulating cell metabolism or physiology

435 6, 435 9131, 4351723, 4352523, 4353201, 435325, 435366, 435410, 536 231, 536 232, 536 245, 514 44, C12N 1500, C12Q 618, C07H 2104

Patent

active

058693394

ABSTRACT:
A synthetic RNA catalyst capable of cleaving an RNA substrate, the catalyst comprising a substrate binding portion and a "hairpin" portion. The invention also provides an engineered DNA molecule and a vector, each comprising a DNA sequence coding for an RNA catalyst according to the invention. The invention further comprises host cells transformed with the vectors of the invention which are capable of expressing the RNA catalyst. Finally, the invention provides a method of cleaving an RNA substrate which comprises contacting the substrate with a synthetic RNA catalyst according to the invention.

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