HIV targeted hairpin ribozymes

Details HIV targeted hairpin ribozymes HIV targeted hairpin ribozymes

1993-11-16

1996-06-18

LeGuyader, John L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 231, 536 245, 435 6, 435 9131, 4351723, 435199, 4352402, 4353201, C12H 1554, C12H 1585, C12H 922, A61K 3170

Patent

active

055278957

ABSTRACT:
A synthetic RNA catalyst capable of cleaving an RNA substrate, the catalyst omprising a substrate binding portion and a "hairpin" portion. The invention also provides an engineered DNA molecule and a vector, each comprising a DNA sequence coding for an RNA catalyst according to the invention. The invention further comprises host cells transformed with the vectors of the invention which are capable of expressing the RNA catalyst. Finally, the invention provides a method of cleaving an RNA substrate which comprises contacting the substrate with a synthetic RNA catalyst according to the invention.

REFERENCES:
Barinaga, Science 262:1512-1514 (1993).
Johnston et al. Science 260:1286-1293 (1993).
Sarver et al. Science 247:1222 (1990).
Rossi et al. J. Cell. Biochem. (Suppl. 14A, D428) 1990.
Buzayan et al. Nature 323:349 (1986).
Cech Science 236:1532 (1987).
Bruening et al. RNA Genetics, vol. II (CRC Press 1988) pp. 127-145.
Uhlenbeck Nature 334:585 (1987).
Haseloff et al. Nature 334:585 (1988).
Forester et al. Cell 50:9-16 (1987).
Diener et al. PNAS 83:58-62 (1986).
Pace et al. Gene 82:65-75 (1989).

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