HIV-specific T-cell induction

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Amino acid sequence disclosed in whole or in part; or...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C424S185100, C424S186100, C424S187100, C530S324000, C530S325000, C530S826000

Reexamination Certificate

active

10673671

ABSTRACT:
This invention discloses diagnostic, preventative, and treatment therapies of AIDS involving determining whether a subject exhibits an HLA-Cw7-restricted CTL response. Some methods are directed to the use of HLA-Cw7 as a genetic marker for long-term non-progression and amenability to treatment therapies. Diagnostic methods include a method for predicting long term non-progression in an HIV-infected subject. Preventative and treatment methods encompass determining whether a subject exhibits or can exhibit an HLA-Cw7-restricted CTL response. They also encompass ways of eliciting such a response, if necessary. Furthermore, some of the methods involve administering one or more HIV polypeptides or peptides, or polynucleotides encoding them, as a treatment therapy to prevent the development of AIDS.

REFERENCES:
patent: 3791932 (1974-02-01), Schuurs et al.
patent: 3949064 (1976-04-01), Bornstein et al.
patent: 4174384 (1979-11-01), Ullman et al.
patent: 4367110 (1983-01-01), Yoshikawa
patent: 4452901 (1984-06-01), Gordon et al.
patent: 4554101 (1985-11-01), Hopp
patent: 4578770 (1986-03-01), Mitani
patent: 4596792 (1986-06-01), Vyas
patent: 4599230 (1986-07-01), Milich et al.
patent: 4601903 (1986-07-01), Frasch
patent: 4608251 (1986-08-01), Mia
patent: 4683195 (1987-07-01), Mullis et al.
patent: 4683202 (1987-07-01), Mullis
patent: 4690915 (1987-09-01), Rosenburg
patent: 4797368 (1989-01-01), Carter et al.
patent: 4800159 (1989-01-01), Mullis et al.
patent: 4883750 (1989-11-01), Whiteley et al.
patent: 4942628 (1990-07-01), Rosen et al.
patent: 5028592 (1991-07-01), Lipton
patent: 5128319 (1992-07-01), Arlinghaus
patent: 5139941 (1992-08-01), Muzyczka et al.
patent: 5142025 (1992-08-01), Putney et al.
patent: 5199942 (1993-04-01), Gillis
patent: 5221605 (1993-06-01), Bard et al.
patent: 5238808 (1993-08-01), Bard et al.
patent: 5279721 (1994-01-01), Schmid
patent: 5310687 (1994-05-01), Bard et al.
patent: 5620896 (1997-04-01), Herrmann et al.
patent: 5780036 (1998-07-01), Chisari
patent: 5958895 (1999-09-01), Pachuk et al.
patent: 6210873 (2001-04-01), Sastry et al.
patent: 6271198 (2001-08-01), Braisted et al.
patent: 0 267 802 (1988-05-01), None
patent: 0 273 716 (1988-07-01), None
patent: 0 284 587 (1988-09-01), None
patent: 320308 (1989-06-01), None
patent: 329822 (1989-08-01), None
patent: 2202328 (1988-09-01), None
patent: WO 88/10315 (1988-12-01), None
patent: WO 89/03844 (1989-05-01), None
patent: WO 89/06700 (1989-07-01), None
patent: WO 89/07112 (1989-08-01), None
patent: WO 90/07641 (1990-07-01), None
patent: WO 93/10816 (1993-06-01), None
patent: WO 93/19775 (1993-10-01), None
patent: WO 96/33734 (1996-10-01), None
Agren et al., “Genetically engineered nontoxic vaccine adjuvent that combines B cell targeting with immunomodulation by cholera toxin A1 subunit,”J. Immunol. 158:3936-3946, 1997.
Aichele et al., “Antiviral cytotoxic T cell response induced by in vivo priming with a free synthetic peptide,”J. Exp. Med., 171:1815-1820, 1990.
Altman et al., “Phenotypic analysis of antigen-specific T lymphocytes,”Science, 274:94-96, 1996.
An and Whitton, “A multivalent minigene vaccine, containing B-cell, cytotoxic T-lymphocyte, and Thepitopes from several microbes, induces appropriate responses in vivo and confers protection against more than one pathogen,”J. Virol., 71(3):2292-2302, 1997.
Barry et al., “Protection against mycoplasma infection using expression-library immunization,”Nature, 377:632-635, 1995.
Berzofsky, “Development of artificial vaccines against HIV using defined epitopes,”FASEB J., 5:2412-2418, 1991.
Bevan, “Stimulating killer cells,”Nature, 342:478-479, 1989.
Bogedain et al., “Specific cytotoxic T lymphocytes recognize the immediate-early transactivator ZTA of Epstein-Barr virus,”J. Virol., 69(8):4872-4879, 1995.
Boyson et al., The MHC class I genes of the rhesus monkey,J. Immunol. 156:4656-4665, 1996.
Braciale et al., “Antigen presentation pathways to class I and class II MHC-restricted T lymphocytes,”Immunol. Rev., 98:95-114, 1987.
Carmichael et al., “Quantitative analysis of the human immunodeficiency virus Type I (HIV-1)-specific cytotoxic T lymphocyte (CTL) response at different stages of HIV-1 infection: differential CTL responses to HIV-1 and Epstein-Barr virus in late disease,”J. Exp. Med., 177:249-256, 1993.
Casement et al., “Cross-reactive cytotoxic T lymphocytes induced by V3 loop synthetic peptides from different strains of human immunodeficiency virus type I,”Virology, 211(1):261-67 1995.
Chopra et al., “Cloning and expression of putative cytotonic enterotoxin-encoding genes fromAeromonas hydrophila,” Gene139:87-91, 1994.
Chopra et al., Molecular and biochemical characterization of a heat-labile cytotonic enterotoxin fromAeromonas hydrophila, Microbial Path. 21:357-377, 1996.
Ciernik et al., “Induction of cytotoxic T lymphocytes and antitumor immunity with DNA vaccines expressing single T cell epitopes,”J. Immunol., 156:2369-2375, 1996.
Clerget-Raslain et al., “Specificity of anti-peptide antibodies elicited against synthetic peptides mimicking conserved regions of HIV1 envelope glycoprotein,”Res. Virol., 142:423-438, 1991.
Dadaglio et al., “Epitope recognition of conserved HIV envelope sequences by human cytotoxic T lymphocytes,”J. Immunol., 147:2302-2309, 1991.
Dai et al., “Mutation of human immunodeficiency virus type 1 at amino acid 585 on gp41 results in loss of killing by CD8+A24-restricted cytotoxic T lymphocytes,”J. Virol., 66:3151-3154, 1992.
De Rossi et al., “Synthetic peptides from the principal neutralizing domain of human immunodeficiency virus type 1 (HIV-1) enhance HIV-1 infection through a CD4-dependent mechanism,”Virology, 184:187-196, 1991.
Gorse et al., “Recombinant gp160 vaccination schedule and MHC HLA type as factors influencing cellular responses to HIV-1 envelope glycoprotein,”Vaccine, 13(13):1170-1179, 1995.
Goulder et al., “Novel, cross-restricted, conserved and immunodominant cytotoxic T lymphocyte epitopes in slow progressors in HIV type I infection,”AIDS Res. Hum. Retroviruses, 12(18):1691-1698, 1996.
Gussow et al., “Isolation, expression and the primary structure ofHLA-Cw1andHLA-Cw2genes: evolutionary aspects,”Immunogenetics, 25:313-322, 1987.
Imaoka et al., “Nasal immunization of nonhuman primates with simian immunodeficency virus p. 55gagand cholera toxin adjuvant induces Th1/Th2 help for virus specific immune responses in reproductive tissues,”J. Immunol., 161:5952-5958, 1998.
Ishioka et al., “Utilization of MHC class I transgenic mice for development of minigene DNA vaccines encoding multiple HLA-restricted CTL epitopes,”J. Immunol., 162:3915-3925, 1999.
Jassoy et al., “Detection of a vigourous HIV-1-specific cytotoxin T lymphocyte response in cerebrospinal fluid from infected persons with AIDS dementia complex,”J. Immunol., 149:3113-3119, 1992.
Johnson et al., “Identification of overlapping HLA class I-restricted cytotoxic epitopes in a conserved region of the human immunodeficiency virus type 1 envelope glycoprotein: definition of minimum epitopes and analysis of the effects of sequence variation,”J. Exp. Med., 175:961-971, 1992.
Johnson et al., “Recognition of a highly conserved region of human immunodeficiency virus type 1 gp120 by an HLA-Cw4-restricted cytotoxic T-lymphocyte clone,”J. Virol., 67(1):438-445, 1993.
Kast et al., “Protection against lethal Sendai virus infection by in vivo priming of virus-specific cytotoxic T lymphocytes with a free synthetic peptide,”Proc. Nat'l Acad. Sci. USA, 88:2283, 1991.
Keusch et al., “Classification of enterotoxins on the basis of activity in cell culture,”J. Infect. Dis. 131(1):58-63, 1973.
Klein et al., “Kinetics of gag-specific cytotoxic T-lymphocyte responses during the clinical course of

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

HIV-specific T-cell induction does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with HIV-specific T-cell induction, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and HIV-specific T-cell induction will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3862719

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.