Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 15 to 23 amino acid residues in defined sequence
Patent
1996-04-04
1998-06-09
Smith, Lynette F.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
15 to 23 amino acid residues in defined sequence
530350, 530395, 4241881, 4241841, 4242081, 4242041, A61K 3800, A61K 3921, C07K 500, C07K 700
Patent
active
057635749
ABSTRACT:
Immunological conjugates of HIV-specific selected principal neutralization epitopes are prepared. These epitopes bind 19b, a broadly neutralizing human monoclonal antibody specific for the HIV gp120. The epitopes are identified from oligopeptide epitope libraries. The conjugates are useful for vaccination against AIDS or ARC, as well as in the production of other HIV-specific broadly neutralizing antibodies for passive immunity against AIDS or ARC.
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Cwirla, et al, 1990, "Reptides on phage: a vast . . . " PNAS 87:6378-6382.
Schild, et al, 1990, "Human immunodeficiency Virus . . . ". The Lancet vol. 335: 1081-1084.
Cohen, 1993, "Jitters Jeopardize AIDS . . . " Science vol. 262: 980-981.
Fox, "No Winners Against AIDS", Biotechnology vol. 12, p. 128, 1994.
Haynes, "Scientific and Social Issues of Human Immuno. . . . " Science, vol. 260, pp. 1279-1286, 1993.
Arnold Beth A.
Boots Lynn J.
Conley Anthony J.
Keller Paul M.
Coppola Joseph A.
Giesser Joanne M.
Merck & Co. , Inc.
Smith Lynette F.
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