Chemistry: molecular biology and microbiology – Spore forming or isolating process
Patent
1994-05-17
1997-09-23
Fleisher, Mindy
Chemistry: molecular biology and microbiology
Spore forming or isolating process
4352401, 4353201, 536 231, C12N 1586, C12N 1511, C12N 510
Patent
active
056703619
ABSTRACT:
This invention provides an infectious retrovirus having inserted between the 5' and 3' long terminal repeat sequences of the retrovirus a nucleic acid encoding an anti-HIV-type specific agent under the control of a pol III promoter. Host cells containing the retroviral vectors of this invention also are provided. Further provided are methods of interfering with or preventing HIV viral replication in a cell infected with HIV or likely to be infected with HIV.
REFERENCES:
patent: 4987071 (1991-01-01), Cech et al.
patent: 5037746 (1991-08-01), Cech et al.
patent: 5093246 (1992-03-01), Cech et al.
patent: 5116742 (1992-05-01), Cech et al.
patent: 5144019 (1992-09-01), Rossi et al.
patent: 5149796 (1992-09-01), Rossi et al.
patent: 5168053 (1992-12-01), Altman et al.
patent: 5180818 (1993-01-01), Cech et al.
patent: 5254678 (1993-10-01), Haseloff et al.
Sullenger, et al., "Expression of Chimeric tRNA-Driven Antisense Transcripts Renders NIH 3T3 Cells Highly Resistant to Moloney Murine Leukemia Virus Replication," Molecular and Cellular Biology (Dec. 1990) 10(12): 6512-6523.
Biberfeld, et al., "HTLV-III Expression in Infected Lymph Nodes and Relevance to Pathogenesis of Lymphadenopathy" AJP 123:436-442 (1986).
Gartner et al., "The Role of Mononuclear Phagocytes in HTLV-III/LAV Infection" Science 233:215-219 (1986).
Mitsuya et al., "Molecular Targets for AIDS Therapy" Science 249:1533-1543 (1990).
Saiki et al., "Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase" Science 239:487-491 (1988).
Ou et al., "DNA Amplification for Direct Detection of HIV-1 in DNA of Peripheral Blood Mononuclear Cells" Science 239:295-297 (1988).
Yamada et al., "Inhibition of Growth of HIV by Human Natural Interferon In Vitro" Aids Research and Human Retroviruses 4:287-294 (1988).
Haseloff and Gerlach, "Simple RNA enzymes with new and highly specific endoribonuclease activities" Nature 334:585-591 (1988).
Hampel and Tritz, "RNA Catalytic Properties of the Minimum (-)sTRSV Sequence" Biochemistry 28:4929-4933 (1989).
Baltimore, D., "Intracellular immunization" Nature 335:395-396 (1988).
Friedman et al., "Expression of a truncated virus trans-activator selectively impedes lytic infection by its cognate virus" Nature 335:452-454 (1988).
Freed et al., "A mutation in the human immunodeficiency virus type 1 transmembrane glycoprotein gp41 dominantly interferes with fusion and infectivity" Proc. Natl. Acad. Sci. USA 89:70-74 (1992).
Steffy and Wong-Staal, "Transdominant Inhibition of Wild-Type Human Immunodeficiency Virus Type 2 Replication by an Envelope Deletion Mutant" J. of Virology 67:1854-1859 (1993).
Sullenger et al., "Overexpression of TAR Sequences Renders Cells Resistant to Human Immunodeficiency Virus Replication" Cell 63:601-608 (1990).
Lisziewicz et al., "Tat-Regulated Production of Multimerized TAR RNA Inhibits HIV-1 Gene Expression" The New Biologist 3:82-89 (1991).
Edgington, Stephen M., ed. "Ribozymes' Patent History" Bio/Technology 11:624-625 (1993).
Alizon et al., "Genetic Variability of the AIDS Virus: Nucleotide Sequence Analysis of Two Isolates from African Patients"; Cell 46:63-74 (1986).
Cassel et al., "Retroviral-Mediated Gene Transfer into CD34-enriched Human Peripheral Blood Stem Cells"; Exp. Hematology 21:585-591 (1993).
Chang et al., "Ribozyme-Mediated Site-Specific Cleavage of the HIV-1 Genome"; Clinical Biotechnology 2(1): 23-31 (1990).
Culver et al., "Correction of ADA Deficiency in Human T Lymphocytes Using Retroviral-Mediated Gene Transfer"; Transplantation Proceedings; 23(1):170-171 (1991).
Gurgo et al., "Short Communications--Envelope Sequences of Two New United States HIV-1 Isolates"; Virology 164:531-536 (1988).
Fauser A.A., "Long-Term Expression of Gene Introduction Into Normal Human T-Lymphocytes by Retroviral-Mediated Gene Transfer"; Journal of Cellular Biochemistry 45:353-358 (1991).
Forster and Symons, "Self-Cleavage of Plus and Minus RNAs of a Virusoid and a Structural Model for the Active Sites"; Cell 49:211-220 (1987).
Haas et al., "Successful Autologous Transplantation of Blood Stem Cells Mobilized with Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor"; Exp. Hematology 18:94-98 (1990).
Hampel, "`Hairpin` Catalytic RNA Model: Evidence for Helices and Sequence Requirement for Substrate RNA"; Nucleic Acids Research 18(2): 299-304 (1990).
Kikukawa et al., "Differential Susceptibility to the Acquired Immunodeficiency Syndrome Retrovirus in Cloned Cells of Human Leukemic T-Cell Line Molt-4"; Journal of Virology 57(3):1159-1162 (1986).
Korbling et al., "Autologous Transplantation of Blood-Derived Hemopoietic Stem Cells After Myeloablative Therapy in a Patient with Burkitt's Lymphoma"; Blood 67(2):529-532 (1986).
Lu et al., "High Efficiency Retroviral-Mediated Gene Transduction into CD34+ Cells Purified from Peripheral Blood of Breast Cancer Patients Primed with Chemotherapy and Granulocyte-Macrophage Colony-Stimulating Factor"; Human Gene Therapy 5:203-208 (1994).
Ratner et al., "Complete Nucleotide Sequences of Functional Clones of the AIDS Virus"; AIDS Research and Human Retroviruses 3:57-69 (1987).
Sanchez-Pescador et al., "Nucleotide Sequence and Expression of an AIDS-Associated Retrovirus (ARV-2)"; Science 227:484-491 (1985).
Starcich et al., "Characterization of Long Terminal Repeat Sequences of HTLV-III"; Science; 227:538-540 (1991).
Talbott et al., "Mapping the Determinants of Human Immunodeficiency Virus 2 for Infectivity, Replication Efficiency and Cytopathicity"; Proc. Natl. Acad. Sci. USA 90:4226-4230 (1988).
Walbot and Bruening, "Plant Development and Ribozymes for Pathogens"; Nature 334:196 (1988).
Ojwang et al., "Inhibition of human immunodeficiency virus type 1 expression by a hairpin ribozyme" Proc. Natl. Acad. Sci. USA 89:10802-10806 (1992).
Rossi et al., "The potential use of catalytic RNAs in therapy of HIV infection and other diseases" Pharmac. Ther. 50:245-254 (1991).
Koch and Ruprecht, "Animal models for anti-AIDS therapy" Antiviral Research 19:81-109 (1992).
Sarvar et al., "Ribozymes as Potential Anti-HIV-1 Therapeutic Agents" Science 247:1222-1225 (1990).
Lo et al., "Inhibition of Replication of HIV-1 by Retroviral Vectors Expressing tat-Antisense and Anti-tat Ribozyme RNA" Virology 190:176-183.
Miller, A. D., "Human gene therapy comes of age" Nature 357:455-460 (1992).
Herskowitz, I., "Functional inactivation of genes by dominant negative mutations" Nature 329:.
Joseph et al., "Substrate selection rules for the hairpin ribozyme determined by in vitro selection, mutation, and analysis of mismatched substrates" Genes & Development 7:130-138 (1993).
Cech and Bass, "Biological Catalysis by RNA" Ann. Rev. Biochem. 55:599-629 (1986).
Geiduschek, E.P., "Transcription by RNA polymerase III" Ann. Rev. Biochem. 57:873-914 (1988).
Arya et al., "Trans-Activator Gene of Human T-Lymphotropic Virus Type III (HTLV-III)" Science 229:69-73 (1985).
Jennings and Molloy, "Inhibition of SV40 replicon function by engineered antisense RNA transcribed by RNA polymerase III" The EMBO Journal 6:3043-3047 (1987).
Sullenger et al., "Expression of Chimeric tRNA-Driven Antisense Transcripts Renders NIH 3T3 Cells Highly Resistant to Moloney Murine Leukemia Virus Replication" Molecular and Cellular Biology 10:6512-6523 (1990).
Cotten and Birnstiel, "Ribozyme mediated destruction of RNA in vivo" 8:3861-3866 (1989).
Sarver et al., "Catalytic RNAs (Ribozymes): A New Frontier in Biomedical Applications" in: AIDS Research Reviews, eds. Koff, Wong-Staal & Kennedy (Marcel Dekker, Inc., New York) vol. 2, pp. 259-285 (1992).
Bass and Weintraub, "An Unwinding Activity that Covalently Modifies its Double-Stranded RNA Substrate" Cell 55:1089-1098 (1988).
Dropulic et al., "Functional Characterization of a U5 Ribozyme: Intracellular Suppression of Human Immunodeficiency Virus Type 1 Expression" J. of Virology 66:1432-1441 (1992).
Yamada et al., "A new method for extracting DNA or RNA for polymerase chain reaction" J. of Virological Meths. 27:203-210 (1990).
Chomczynski and Sacchi, "Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate
Ho Anthony
Leavitt Markley C.
Ojwang Joshua O.
Wong-Staal Flossie
Yamada Osamu
Fleisher Mindy
Railey II Johnny F.
The Regents of the University of California
LandOfFree
HIV-specific ribozymes does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with HIV-specific ribozymes, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and HIV-specific ribozymes will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1938342