HIV-specific CTL inducing peptides and medicaments for...

Details HIV-specific CTL inducing peptides and medicaments for... HIV-specific CTL inducing peptides and medicaments for...

2005-03-22

2005-03-22

Tate, Christopher (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C435S005000, C435S006120, C435S091200, C536S023100, C536S023720

Reexamination Certificate

active

06869933

ABSTRACT:
Peptides which can induce specific CTLs for HIV, DNAs encoding for the peptides and medicaments for preventing and/or treating HIV comprising the peptides are provided. According to the present invention, peptides carrying novel CTL epitopes derived from HIV Pol or Env proteins are provided. These peptides can bind to HLA-A11, particularly HLA-A*1101 which is frequently encountered in Japanese people and induce HIV-specific cytotoxic T cells.

REFERENCES:
patent: 5756666 (1998-05-01), Takiguchi et al.
patent: 6037135 (2000-03-01), Kubo et al.
patent: 9511255 (1995-04-01), None
patent: WO 0026416 (2000-05-01), None
Wilson C.C., et al. “Frequent detection of escape from cytotoxic T-lymphocyte recognition in perinatal human immunodeficiency virus (HIV) type 1 transmission: the ariel project for the prevention of transmission of HIV from mother to infant”, Journal of Virology (May 1999), vol. 73, No. 5, pp. 3975-3985.
Lole K.S., et al. “Fill-length human immunodeficiency virus type 1 genomes from subtype C-infected seroconverters in India, with evidence of intersubtype recombination”, Journal of Virology (Jan. 1999), vol. 73, No. 1, pp. 152-160.
Borrow P., et al. “Antiviral pressure exerted by HIV-1-specific cytotoxic T lymphocytes during primary infection demonstrated by rapid selection of CTL escape virus”, Nature Medicine (1997), vol. 3, No. 2, pp. 205-211.
Couillin I, et al., “Impared cytotoxic T lymphocyte recognition due to genetic variations in the main immunogenic region of the human immunodeficiency virus 1 NEF protein”, J. Exp. Med. (1994), vol. 180, No. 3, pp. 1129-1134.

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