HIV reverse transcriptase inhibitors

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C514S301000, C514S302000, C514S303000, C514S359000, C514S406000, C514S394000, C514S205000, C544S205000, C546S112000, C546S113000, C546S114000, C546S117000, C546S118000, C548S216000, C548S304100

Reexamination Certificate

active

07807684

ABSTRACT:
Compounds having the structure:are HIV reverse transcriptase inhibitors, wherein A, X, Y, Z, R1and R2are defined herein. The compounds and their pharmaceutically acceptable salts are useful in the inhibition of HIV reverse transcriptase, the prophylaxis and treatment of infection by HIV and in the prophylaxis, delay in the onset, and treatment of AIDS. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.

REFERENCES:
patent: 3600437 (1971-08-01), Marshall
patent: 4404018 (1983-09-01), Stach et al.
patent: 4443248 (1984-04-01), Hokama
patent: 4599105 (1986-07-01), Malhotra et al.
patent: 5164407 (1992-11-01), Greenlee et al.
patent: 5389660 (1995-02-01), Greenlee et al.
patent: 5648368 (1997-07-01), Egbertson et al.
patent: 5665737 (1997-09-01), Cavalla et al.
patent: 5710171 (1998-01-01), Dinsmore et al.
patent: 5739144 (1998-04-01), Warrellow et al.
patent: 5744492 (1998-04-01), Kohn et al.
patent: 5994376 (1999-11-01), Freyne et al.
patent: 6057346 (2000-05-01), Kohn et al.
patent: 6117886 (2000-09-01), Timmerman et al.
patent: 6348032 (2002-02-01), Sperl et al.
patent: 7166738 (2007-01-01), Dunn et al.
patent: 7208509 (2007-04-01), Dunn et al.
patent: 7348345 (2008-03-01), Dunn et al.
patent: 7625949 (2009-12-01), Dunn et al.
patent: 7666891 (2010-02-01), Dunn et al.
patent: 2003/0100554 (2003-05-01), Jones et al.
patent: 2004/0006114 (2004-01-01), Coleman et al.
patent: 2004/0122064 (2004-06-01), Chan
patent: 2004/0242654 (2004-12-01), Kohno et al.
patent: 2005/0095215 (2005-05-01), Popp
patent: 2005/0197340 (2005-09-01), Arora et al.
patent: 2005/0203091 (2005-09-01), Arora et al.
patent: 2005/0209282 (2005-09-01), Wilson et al.
patent: 2005/0228000 (2005-10-01), Smallheer et al.
patent: 2008/0045511 (2008-02-01), Kennedy-Smith et al.
patent: 1120034 (1982-03-01), None
patent: 0 003 584 (1979-08-01), None
patent: 0 003 584 (1979-08-01), None
patent: 0 011 802 (1980-06-01), None
patent: 0 281 103 (1988-09-01), None
patent: 0 537 538 (1993-04-01), None
patent: 0 622 077 (1994-11-01), None
patent: 1 431 267 (2004-06-01), None
patent: 1 584 619 (2005-10-01), None
patent: 1 208 091 (2006-05-01), None
patent: 1 661 879 (2006-05-01), None
patent: 56002965 (1981-01-01), None
patent: WO 96/37204 (1996-11-01), None
patent: WO 98/01428 (1998-01-01), None
patent: WO 00/68201 (2000-11-01), None
patent: WO 02/070470 (2002-09-01), None
patent: WO 02/074726 (2002-09-01), None
patent: WO 03/048134 (2003-06-01), None
patent: WO 2004/019941 (2004-03-01), None
patent: WO 2004/085406 (2004-10-01), None
patent: WO 2004/085411 (2004-10-01), None
patent: WO 2004/096807 (2004-11-01), None
patent: WO 2005/099709 (2005-10-01), None
patent: WO 2005/105766 (2005-11-01), None
patent: WO 2006/067587 (2006-06-01), None
patent: WO 2006/076706 (2006-07-01), None
patent: WO 2006/077025 (2006-07-01), None
English Translation of JP56002965, Mitsui Toatsu Chemicals, Jan. 1981.
Chintakunta, V. et al. “3-O-Substituted benzyl pyridazinone derivatives as COX inhibitors”, European Journal of Medicinal Chemistry, 2002, vol. 37, pp. 339-347.
De Lucca, G. et al. “Nonsymmetric P2/P2′ Cyclic Urea HIV Protease Inhibitors. Structure-Activity Relationship, Bioavailabilty, and Resistance Profile of Monoindazole-Substituted P2 Analogues”, Journal of Medicinal Chemistry, 1998, vol. 41, pp. 2411-2423.
Doskotch, R. et al. “Codonocarpus Alkaloids-III The Structure of Codonocarpine”, Tetrahedron, 1974, vol. 30, pp. 3229-3236.
Feit, P. et al. “Aminobenzoic Acid Diuretics. 3.1 4-Substituted 5-Sulfamylanthranilic Acid Derivatives”, Journal of Medicinal Chemistry, 1972, vol. 15, pp. 79-83.
Li, X. et al. “A novel phase-switching protecting group for multi-step parallel solution phase synthesis”, Organic and Biomolecular Chemistry, 2004, vol. 2, pp. 989-998.
Musser, J. et al. “N-[(Arylmethoxy)phenyl] Carboxylic Acids, Hydroxamic Acids, Tetrazoles and Sulfonyl Carboxamides. Potent Orally Active Leukotriene D4 Antagonists of Novel Structure”, Journal of Medicinal Chemistry, 1990, vol. 33, pp. 240-245.
Nandihalli, U. et al. “Enantioselectivity of Protoporphyrinogen Oxidase-Inhibiting Herbicides”, Pesticide Science, 1994, vol. 40, pp. 265-277.
Papot, S. et al. “Design of Selectivity Activated Anticancer Prodrugs: Elimination and Cyclization Strategies”, Current Medicinal Chemistry—Anti Cancer Agents, 2002, vol. 2, pp. 155-185.
Saari, W. et al. “Cyclization-Activated Prodrugs. Basic Carbamates of 4-Hydroxyanisole”, Journal of Medicinal Chemistry, 1990, vol. 33, pp. 97-101.
Santos, C. et al. “Cyclization-activated prodrugs. Synthesis, reactivity and toxicity of dipeptide esters of paracetamol”, Bioorganic & Medicinal Chemistry Letters, 2005, vol. 15, pp. 1595-1598.
Wyatt, P. et al. “Benzophenone Derivatives: A Novel Series of Potent and Selective Inhibitors of Human Immunodeficiency Virus Type 1 Reverse Transcriptase”, Journal of Medicinal Chemistry, 1995, vol. 38, pp. 1657-1665.
Database CHEMCATS, Accession No. 2006:3663485, XP002413978, Jan. 24, 2006.
Database CHEMCATS, Accession No. 2006:3640051, XP002413979, Jan. 24, 2006.
Database CHEMCATS, Accession No. 2006:3646612, XP002413980, Jan. 24, 2006.
Database Beilstein, Beilstein Registry No. 10083060, XP002414728, Apr. 2005.
CAPLUS Database, Accession No. 1981:46881, Abstract of Schoenowsky et al., “Nitrodiphenyl ethers, their preparation and herbicidal activity”, Zeitschrift fuer Naturforschung, 1980, vol. 35B, pp. 902-908. XP002414729.
CAPLUS Datbase, Accession No. 2005:1042231, Kawamoto et al., “Preparation and heterocyclic compounds as G protein-coupled receptor kinase (GRK) inhibitors”, Abstract of WO 2005/090328 (Takeda Pharmaceuticals Co., Ltd.).
Derwent Abstract No. 93-127048/16, “Fluorinated phenoxy-phenoxy-carboxylic acid derivatives”, Abstract of DE 4133674-A1, 1993, (Bayer AG) (corresponds to EP 0 537 538).
Derwent Abstract No. 61653B/34, “Meta-aryloxy-phenoxy-propionic acid derivatives—useful as herbicides”, Abstract of DT 2805-981, 1978, (Bayer AG) (corresponds to EP 0 003 584).
Derwent Abstract No. 2003-541543/51, “Sodium-phosphate cotransporter inhibitors comprise new and known triazole compounds”, Abstract of WO 2003048134A1, 2003, (Japan Tobacco).

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