HIV related peptides, immunogenic antigens, and use therefor as

Details HIV related peptides, immunogenic antigens, and use therefor as HIV related peptides, immunogenic antigens, and use therefor as

1989-01-23

1991-01-08

Lee, Lester L.

Drug, bio-affecting and body treating compositions

Lymphokine

424 89, 530324, 530325, 530326, 530345, 530403, 530806, 530807, A61K 3912, C07K 708, C07K 710, C07K 1708

Patent

active

049833871

ABSTRACT:
Vaccines effective in the inhibition of infection caused by the family of retroviruses, HTLV-III, Human T-Cell Leukemia Virus, LAV, Lymphadenopathy-associated virus, ARV-2, AIDS-Related Virus, (AIDS and AIDS-Related Complex) have been developed from an antisera prepared against thymosin .alpha..sub.1 (T.alpha..sub.1), a thymic hormone, as well as from antisera to synthetic peptide fragments of T.alpha..sub.1 and antisera to synthetic peptide inclusive of amino acid positions 92-109 of the p17 gag core protein of HTLV-III, LAV and ARV-2. In this 18 amino acid primary sequence that is a 44 to 50% homology between the gag protein and T.alpha..sub.1. Immunoglobulin (IgG)- enriched preparations of the T.alpha..sub.1 antisera have enhanced activity in blocking viral replication. A diagnostic test capable of directly detecting the presence of HTLV-III, LAV, ARV-2 and related retroviruses associated with AIDS and ARC is also described.

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