Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1995-03-21
1996-06-18
Richter, Johann
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
A61K 31495
Patent
active
055277993
ABSTRACT:
Compounds of formula ##STR1## where R.sup.1 and R.sup.2 are independently hydrogen or optionally-substituted C.sub.1-4 alkyl or aryl, or R.sup.1 and R.sup.2 are joined together to form a monocyclic or bicyclic ring system, are HIV protease inhibitors. These compounds are useful in the prevention or treatment of infection by HIV and in the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.
REFERENCES:
patent: 5192764 (1993-03-01), Cheng et al.
patent: 5413999 (1995-05-01), Vacca et al.
Dorsey Bruce D.
Guare James P.
Holloway M. Katharine
Hungate Randall W.
Levin Rhonda B.
Merck & Co. , Inc.
Meredith Roy D.
Peabody John
Richter Johann
Tribble Jack L.
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