HIV Protease inhibitors useful for the treatment of AIDS

Details HIV Protease inhibitors useful for the treatment of AIDS HIV Protease inhibitors useful for the treatment of AIDS

1996-05-02

1997-09-16

Richter, Johann

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514262, A61K 3144

Patent

active

056681321

ABSTRACT:
Compounds of formula ##STR1## where R.sup.1 and R.sup.2 are independently hydrogen or optionally-substituted C.sub.1-4 alkyl or aryl, and R.sup.1 also forms a heterocycle or heterocycle-C.sub.1-4 alkyl, are HIV protease inhibitors. These compounds are useful in the prevention or treatment of infection by HIV and in the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.

REFERENCES:
patent: 5527799 (1996-06-01), Vacca et al.
Webb et al., Nucleosides & Nucleotides, 7(2), pp. 147-153 (1988).
Mitsuya et al., Proc., Natl. Acad. Sci., USA , vol. 83, pp. 1911-1915, March 1986.
Douglas D. Richman, Antimicrobial Agents and Chemotherapy, vol. 31, No. 12, pp. 1879-1881, Dec. 1987.

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