HIV protease inhibitors useful for the treatment of AIDS

Details HIV protease inhibitors useful for the treatment of AIDS HIV protease inhibitors useful for the treatment of AIDS

1996-10-21

1998-05-05

Lambkin, Deborah

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

514432, 514456, 514616, 514374, 514415, 514438, 514443, 549 53, 549 58, 549 77, 549 23, 549404, 564158, 564170, 548495, 548238, A61K 31165, A61K 3138, C07D33362, C07C20300

Patent

active

057475407

ABSTRACT:
Compounds such as ##STR1## or pharmaceutically acceptable salts thereof, are HIV protease inhibitors. These compounds are useful in the prevention or treatment of infection by HIV and in the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.

REFERENCES:
patent: 5413999 (1995-05-01), Vacca et al.
Kaldor et al., "New Dipeptide Isosteres Useful for the Inhibition of HIV-1 Protease", Bioorganic & Medicinal Letters, vol. 4 (1994), pp. 1385-1390.

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