Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1994-10-25
1996-03-26
Dentz, Bernard
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546147, C07D21702, A61K 3147
Patent
active
055020607
ABSTRACT:
Oligopeptide analogs are described. These compounds are useful in the inhibition of HIV protease, the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivitals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.
REFERENCES:
Roberts, N.A., et al. "Rational Design of Peptide-Based HIV Proteinase Inhibitors," Science, vol. 248, pp. 358-361 (1990).
Kohl, N. E. et al., "Active HIV protease is required for viral infectivity," Proc. Natl. Acad. Sci. 85, 4686 (1988).
Ratner, L. et al., "Complete nucleotide sequences of . . . HTLV-III," Nature 313, 277 (1985).
Toh, H. et al., "Close structural resemblance . . . ," EMBO J. 4, 1267 (1985).
Power, M. D. et al., "Nucleotide Sequence of SRV-1 . . . ," Science 231, 1567 (1986).
Pearl, L. H. et al., "A Structural Model for the retroviral proteases," Nature 329, 351 (1987).
Skiles, J. W. et al., J. Med. Chem., 29, 784 (1986).
Hein, G. E., et al., "Steric Course and Specificity of Alpha-Chymotrypsin Catalyzed Reactions," J. Am. Chem. Soc. 84, 4489 (1962).
Hayasnik, K. et al., Chem. Pharm. Bull. 31, 312 (1983).
Gao, Y. et al., "Catalytic Asymmetric Epoxidation . . . ," J. Am. Chem. Soc. 109, 5765 (1987).
Caron, M. et al., "Regioselective Azide Opening of 2,3-Epoxy Alcohols . . . ," J. Org. Chem. 53, 5185 (1988).
Ghosh, A. K. et al., Tetrahedron Lett. 32, 4251 (1991).
Jalali-Naini, M. et al., Tetrahedron Lett., 497 (1986).
Ghosh Arun K.
Huff Joel R.
Lee Hee Y.
Thompson Wayne J.
Caruso Charles M.
Davis Zinna N.
Dentz Bernard
Merck & Co. , Inc.
Meredith Roy D.
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