HIV protease inhibitors

Details HIV protease inhibitors HIV protease inhibitors

2006-02-09

2010-10-05

Powers, Fiona T (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S357000, C514S464000, C514S443000, C514S476000, C544S336000, C546S332000, C549S032000, C549S441000, C560S024000, C560S027000

Reexamination Certificate

active

07807677

ABSTRACT:
Compounds of the formula I:whereinR1, R2, X and N are as defined in the specification;E is N, CH;A′ and A″ are terminal groups as defined in the specification.The compounds have utility as HIV-1 protease inhibitors.

REFERENCES:
patent: 6291687 (2001-09-01), Classon et al.
patent: 6489364 (2002-12-01), Classon et al.
patent: 0480 714 (1992-04-01), None
patent: WO 92/15319 (1992-09-01), None
patent: WO 97/40029 (1997-10-01), None
patent: WO98/45330 (1998-10-01), None
patent: WO 2006/084688 (2006-08-01), None
Jenny K. Ekegren et al., “A New Class of HIV-1 Protease Inhibitors Containing a Tertiary Alcohol in the Transition-State Mimicking Scaffold”,J. Med. Chem.: 48, 8098-8102 (2005).
Johanna Wachtmeister et al., ,Tetrahedron 56: 3219-3225 (2000).
Guido Bold et al. “New Aza-Dipeptide Analogues as Potent and Orally Absorbed HIV-1 Protease Inhibitors: Candidates for Clinical Development,”J.Med. Chem: 41, 3387-3401 (1998).

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