HIV protease inhibitors

Details HIV protease inhibitors HIV protease inhibitors

1994-05-23

1996-06-18

O'Sullivan, Peter

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

514117, 514305, 514432, 514444, 514446, 514448, 514603, 514605, 548200, 548201, 549 13, 549 23, 549 71, 549 72, 564 15, 564 86, 564 89, 564 91, 564 92, A61K 3118

Patent

active

055278299

ABSTRACT:
HIV protease inhibitors, obtainable by chemical synthesis, inhibit or block the biological activity of the HIV protease enzyme, causing the replication of the HIV virus to terminate. These compounds, as well as pharmaceutical compositions that contain these compounds and optionally other anti-viral agents as active ingredients, are suitable for treating patients or hosts infected with the HIV virus, which is known to cause AIDS.

REFERENCES:
patent: 5063208 (1991-11-01), Rosenberg et al.
patent: 5142056 (1992-08-01), Kempe et al.
patent: 5157041 (1992-10-01), Handa et al.
patent: 5196438 (1993-03-01), Martin et al.
patent: 5204471 (1993-04-01), Negele et al.
patent: 5235039 (1993-08-01), Heath, Jr. et al.
patent: 5463104 (1995-10-01), Vasquez et al.
Tam et al., J. Med. Chem., 35(7):1318-1320 (1992).
Huff, J. Med. Chem., 34(8):2305-2314 (1991).
Ghosh et al., J. Med. Chem., 36(2):292-294 (1993).
Ghosh et al., J. Med. Chem., 36(16):2300-2310 (1993).
Thompson et al., J. Am. Chem. Soc., 115(2):801-802 (1993).
Rich et al., J. Med. Chem., 34(3):1222-1225 (1991).
Thaisvivongs et al., J. Med. Chem., 34:2344-2356 (1991).
Ghosh et al., J. Med. Chem., 36:924-927 (1993).
Chong et al., J. Med. Chem., 36:2575-2577 (1993).
Vava Pradad et al., Peptides, Chemistry and Biology, Proceedings of the Twelfth American Peptide Symposium, Jun. 16-21, pp. 721-722 (1991).
Rich, et al., Chem. Abstracts, 114(15) Abstract No. 143998q (1991).
Houpis et al., Tetrahedron Letters, 34(16):2593-2596 (1993).
Roberts, N. A. et al., Science, 248:358-361 (1990).
Gilbert et al., J. Chem. Soc. Perkin Trans., 2:475-479 (1993).
Young et al., J. Med. Chem., 35:1702-1709 (1992).
Lyle et al., J. Med. Chem., 34:1228-1230 (1991).

Affiliated with

Also associated with

Rating

HIV protease inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with HIV protease inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and HIV protease inhibitors will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-223296