Chemistry: molecular biology and microbiology – Treatment of micro-organisms or enzymes with electrical or... – Modification of viruses
Patent
1993-03-02
1997-06-10
Stone, Jacqueline M.
Chemistry: molecular biology and microbiology
Treatment of micro-organisms or enzymes with electrical or...
Modification of viruses
435219, 4353201, 536 2372, 930221, 935 33, 935 34, 935 38, C12N 1549, C12N 1563, C12N 1570, C12P 2102
Patent
active
056374887
ABSTRACT:
The invention is a synthetic DNA sequence for encoding a specific enzyme or protease. The protease is essential for the completion (replication) of an infective human immunodeficiency virus (HIV). The invented gene is desirable for the expression of the protease by recombinant methodology in prokaryotic and/or eukaryotic cells and the production of a commercially desirable amount of the protease for biochemical and physical characterization, necessary to find effective inhibitor of the protease, and thereby to block the production of infectious human immunodeficiency virus (HIVs).
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M.C. Graves et al., "An 11-kDa Form of Human Immunodeficiency Virus Protease Expressed in Escherichia coli is Sufficient for Enzymatic Activity"; Proc. Natl. Acad. Sci. USA, vol. 85, Apr. 1988, pp. 2449-2453.
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Medabalimi John L.
Mora Peter T.
Oroszlan Stephen
Railey II Johnny F.
Stone Jacqueline M.
The United States of America as represented by the Department of
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