HIV peptide-inducted T cell stimulation

Details HIV peptide-inducted T cell stimulation HIV peptide-inducted T cell stimulation

1988-06-13

1990-07-24

Lee, Lester L.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

15 to 23 amino acid residues in defined sequence

514 14, 514 15, 514 17, 530328, 530330, 424 89, C07K 708

Patent

active

049436287

ABSTRACT:
The present invention provides peptides derived from HIV-1 which are capable of stimulating T cell proliferation. Such peptides are useful for immunizing human subjects against HIV infection.

REFERENCES:
Aids Research and Human Retroviruses, vol. 4, No. 3, 1988, Yourno et al., pp. 165-174.
Proc. Natl. Acad. Sci. U.S.A., vol. 84, pp. 2479-2483, Apr. 1987, Parker et al.
Journal of Virology, Feb. 1987, pp. 570-578, Modrow et al., Febs Letters, vol. 218, No. 2, 231-237, Jun. 1987, Steinberg et al.
Ratner, L. et al., (1985). Complete Nucleotide Sequence of the Aids Virus, HTLV-III, Nature 313: 277-284.
Putney, S. D. et al., (1988), HTLV-III/LAV-Neutralizing Antibodies to an E. Coli-Produced Fragment of the Virus Envelope, Science 234:1392-1395.
Lasky, L. A. et al., (1987). Delineation of a Region of the Human Immunodeficiency Virus Type 1 gp120 Glycoprotein Critical for Interaction with the CD4 Receptor, Cell 50:975-985.
Cease, K. B. et al., (1987), Helper T-Cell Antigenic Site Identification in the Acquired Immunodeficiency Syndrome Virus gp120 Envelope Protein and Induction of Immunity in Mice to the Native Protein Using a 16-Residue Synthetic Peptide, Proc. Natl. Acad. Sci., U.S.A., 84: 4249-4253.
Ho, D. D. et al., (1988) Second Conserved Domain of gp120 is Important for HIV Infectivity and Antibody Neutralization, Science 239: 1021-1023.
Milich, D. R. et al., (1987), Antibody Production to the Nucleocapsid and Envelope of the Hepatitis B Virus Primed by a Single Synthetic T Cell Site, Nature 329: 547-549.
Krohn, K. et al., (1988), Group Specific Helper T-Cell Response Towards HIV Requires Identification of Two Epitopes on the External Glycoprotein, IV International Conference on Aids, Abstract #1189.
Palker, T. J. et al., (1988), Bivalent Synthetic Peptide Inoculum Elicits High Titers of Neutralizing Antibodies to Human Immunodeficiency Virus (HIV) Isolates HTLV-III and HTLV-III.sub.RF. IV International Conference on Aids, Abstract #1192.
Berzofsky, A. J. et al., (1988), An Immunodominant Epitope of HIV Envelope Recognized by Class I-MHC Restricted Murine Cytotoxic T Cells. IV International Conference on Aids, Abstract #2220.
Warner, J. F. et al., (1988), T Cell Reactive Epitopes from HIV GP120 IV International Conference on Aids, Abstract #2218.
DeLisi, C. and Berzofsky, J. A. (1985), T-Cell Antigenic Sites Tend to be Amphiphgathic Structures, Proc. Natl. Acad. Sci., U.S.A., 82: 7048-7052.

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