HIV matrix protein tyrosine position 29 pocket binders

Details HIV matrix protein tyrosine position 29 pocket binders HIV matrix protein tyrosine position 29 pocket binders

1997-08-15

1998-12-15

Lambkin, Deborah C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514545, 514544, 560 51, 560 10, 560 9, A61K 3122, C07C32100

Patent

active

058497935

ABSTRACT:
There is disclosed a structural genus of compounds, defined according to coordinates in three-dimensional space, that binds amino moieties on neighboring lysine residues in a tyrosine residue 29 pocket of the matrix protein component of the HIV preintegration complex (PIC), thereby preventing the PIC from binding to karyopherin .alpha. and preventing nuclear importation and integration of the HIV viral genome into the host cell DNA, thereby preventing viral infection.

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