HIV integrase inhibitors

Details HIV integrase inhibitors HIV integrase inhibitors

2011-07-19

2011-07-19

Coleman, Brenda L (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S211100, C540S490000, C540S552000

Reexamination Certificate

active

07981879

ABSTRACT:
Compounds of Formula I are inhibitors of FHV integrase and inhibitors of FHV replication (I), wherein m, n, X, R1, R2, R3, R4, R5, R6, R7; R8, R9and R10are defined herein. The compounds are useful for the prophylaxis or treatment of infection by HTV and the prophylaxis, treatment, or delay in the onset of AIDS. The compounds are employed against HTV infection and ADDS as compounds per se or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.

REFERENCES:
patent: 6262055 (2001-07-01), Young et al.
patent: 6306891 (2001-10-01), Selnick et al.
patent: 6380249 (2002-04-01), Young et al.
patent: 6841558 (2005-01-01), Anthony et al.
patent: 6919351 (2005-07-01), Anthony et al.
patent: 6921759 (2005-07-01), Anthony et al.
patent: 7037908 (2006-05-01), Naidu et al.
patent: 7115601 (2006-10-01), Naidu et al.
patent: 7135467 (2006-11-01), Walker et al.
patent: 7157447 (2007-01-01), Naidu et al.
patent: 7169780 (2007-01-01), Crescenzi et al.
patent: 7173022 (2007-02-01), Naidu et al.
patent: 7176196 (2007-02-01), Naidu et al.
patent: 7192948 (2007-03-01), Banville et al.
patent: 7211572 (2007-05-01), Miyazaki et al.
patent: 7217713 (2007-05-01), Crescenzi et al.
patent: 7232819 (2007-06-01), Di Francesco et al.
patent: 7273859 (2007-09-01), Naidu
patent: 7279487 (2007-10-01), Egbertson et al.
patent: 7414045 (2008-08-01), Crescenzi et al.
patent: 7419969 (2008-09-01), Naidu et al.
patent: 7435734 (2008-10-01), Crescenzi et al.
patent: 7459452 (2008-12-01), Di Francesco et al.
patent: 7491819 (2009-02-01), Naidu et al.
patent: 7511037 (2009-03-01), Naidu et al.
patent: 2003/0229079 (2003-12-01), Payne et al.
patent: 2004/0204498 (2004-10-01), Walker et al.
patent: 2004/0229892 (2004-11-01), Naidu et al.
patent: 2004/0229909 (2004-11-01), Kiyama et al.
patent: 2005/0010048 (2005-01-01), Zhuang et al.
patent: 2005/0054645 (2005-03-01), Miyazaki et al.
patent: 2006/0046985 (2006-03-01), Crescenzi et al.
patent: 2006/0106007 (2006-05-01), Naidu et al.
patent: 2006/0276466 (2006-12-01), Naidu et al.
patent: 2007/0083045 (2007-04-01), Di Francesco et al.
patent: 2007/0123524 (2007-05-01), Crescenzi et al.
patent: 2007/0149556 (2007-06-01), Mikamiyama et al.
patent: WO 2005/061490 (2005-07-01), None
patent: WO 2007/064316 (2007-06-01), None
Pearl, L. et al. “A structural model for the retroviral proteases”, Nature, 1987, vol. 329, pp. 351-354.
Power, M. et al. “Nucleotide Sequence of SRV-1, a Type D Simian Acquired Immune Deficiency Syndrome Retrovirus”, Science, 1986, vol. 231, pp. 1567-1572.
Ratner, L. et al. “Complete nucleotide sequence of the AIDS virus, HTLV-III”, Nature, 1985, vol. 313, pp. 277-284.
Thornber, C. “Isosterism and Molecular Modification in Drug Design”, Chemical Society Reviews, 1979, vol. 8, pp. 563-580.
Toh, H. et al. “Close structural resemblance between putative polymerase of aDrosophilatransposable genetic element 17.6 and pol gene product of Moloney murine leukaemia virus”, The EMBO Journal, 1985, vol. 4, pp. 1267-1272.

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