Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2005-03-04
2010-10-26
Wilson, James O (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C544S256000, C544S350000
Reexamination Certificate
active
07820680
ABSTRACT:
Bicyclic uracils and related compounds are inhibitors of HIV integrase and inhibitors of HIV replication. In one embodiment, the compounds are of Formula I:wherein a, b, Y, R1, R2, R3and R4are defined herein. The compounds are useful in the prevention and treatment of infection by HIV and in the prevention, delay in the onset, and treatment of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.
REFERENCES:
patent: 6262055 (2001-07-01), Young et al.
patent: 6306891 (2001-10-01), Selnick et al.
patent: 6380249 (2002-04-01), Young et al.
patent: 6841558 (2005-01-01), Anthony et al.
patent: 6919351 (2005-07-01), Anthony et al.
patent: 6921759 (2005-07-01), Anthony et al.
patent: 7109186 (2006-09-01), Walker et al.
patent: 7169780 (2007-01-01), Crescenzi et al.
patent: 7211572 (2007-05-01), Miyazaki et al.
patent: 7217713 (2007-05-01), Crescenzi et al.
patent: 7232819 (2007-06-01), Di Francesco et al.
patent: 7279487 (2007-10-01), Egbertson et al.
patent: 7435734 (2008-10-01), Crescenzi et al.
patent: 7459452 (2008-12-01), Di Francesco et al.
patent: 7598264 (2009-10-01), Han et al.
patent: 7619086 (2009-11-01), Morrissette et al.
patent: 2003/0055071 (2003-03-01), Anthony et al.
patent: 2003/0229079 (2003-12-01), Payne et al.
patent: 2004/0229909 (2004-11-01), Kiyama et al.
patent: 2005/0010048 (2005-01-01), Zhuang et al.
patent: 2007/0161639 (2007-07-01), Jones et al.
patent: 2008/0275004 (2008-11-01), Crescenzi et al.
patent: 2009/0054399 (2009-02-01), Vacca et al.
patent: 2009/0099168 (2009-04-01), Donghi et al.
patent: 1422218 (2004-05-01), None
patent: WO 01/00578 (2001-01-01), None
patent: WO 02/30426 (2002-04-01), None
patent: WO 02/036734 (2002-05-01), None
patent: WO 02/055079 (2002-07-01), None
patent: WO 03/035076 (2003-05-01), None
patent: WO 03/035077 (2003-05-01), None
patent: WO 03/062204 (2003-07-01), None
patent: WO 2004/004657 (2004-01-01), None
Ratner, L., et al., “Complete Nucleotide Sequence of the AIDS Virus, HTLV-III”, Nature, vol. 313, pp. 277-284, (1985).
Toh, H., et al., “Close Structural Resemblance Between Putative Polymerase of a Drosphila Transposable Genetic Element 17.6 and Pol Gene Product of Moloney Murine Leukemia Virus”, EMBO Journal, vol. 4, No. 5, pp. 1267-1272, (1985).
Power, M.D., et al., “Nucleotide Sequence of SRV-1, a Type D Simian Acquired Immune Deficiency Syndrome Retrovirus”, Science, vol. 231, pp. 1567-1572, (1986).
Pearl, L.H., et al., “A Structural Model for the Retroviral Proteases”, Nature, vol. 329, pp. 351-354, (1987).
Neamati, N., “Patented Small Molecule Inhibitors of HIV-1 Integrase : a 10-Year Saga”, Expert Opinion on Therapeutic Patents, vol. 12, No. 5, pp. 709-724 (2002).
Machon, et al., “Synthesis of Perhydropyrazino[1,2-c]Pyrimidine Derivatives”, Farmaco Edizione Scientifica vol. 40, No. 9, pp. 695-700 (1985).
Selected papers from Interference No. 105,655 between U.S. Appl. No. 10/587,601 (Merck) and US 7,211,572 (Japan Tobacco)—Merck Amended Miscellaneous Motion 1 dated Nov. 10, 2008; Interlocutory Order dated Nov. 18, 2008, Granting Merck's Unopposed Revised Miscellaneous Motion 1; Redeclaration of Interference dated Nov. 18, 2008; Judgement dated Dec. 5, 2008.
Amendment and Response to Restriction Requirement filed Jul. 2, 2009 in U.S. Appl. No. 11/920,032.
Embrey Mark W.
Staas Donnette D.
Wai John S.
Williams Peter D.
Zhuang Linghang
Heber Sheldon O.
McDowell Brian
Merck & Co. , Inc.
Walton Kenneth R.
Wilson James O
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