HIV inhibiting 3,4-dihydro-imidazo[4,5-B]pyridin-5-ones

Details HIV inhibiting 3,4-dihydro-imidazo[4,5-B]pyridin-5-ones HIV inhibiting 3,4-dihydro-imidazo[4,5-B]pyridin-5-ones

2011-08-09

2011-08-09

Aulakh, Charanjit S (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C546S064000, C544S247000, C544S233000, C544S115000, C514S248000, C514S257000

Reexamination Certificate

active

07994187

ABSTRACT:
HIV inhibitory compounds of formula:salts, hydrates, solvates, N-oxides, or stereoisomers thereof, whereinA forms pyridine, pyrimidine, pyrazine, pyridazine, triazine, imidazole, pyrazole, triazole, tetrazole, oxazole, isoxazole, oxadiazole, thiazole, isothiazole, and thiadiazole;R1is halo, cyano, nitro, C1-6alkyl, polyhaloC1-6alkyl, —C1-6alkyl-OR4, —C(═O)—R5, —C(═O)—OR4, —C(═O)—NR6R7, —OR4, —O—C(═O)—C1-6alkyl, —O—C1-6alkyl-OR4, —O—C1-6alkyl-NR6R7, —O—C1-6alkyl-O—C(═O)—C1-6alkyl, —O—C1-6alkyl-C(═O)—OR4, —O—C1-6alkyl-C(═O)—NR6R7, —NR6R7, —NR8—C(═O)—R5, —NR8—C(═O)—OR4, —NR8—C(═O)—NR6R7, —NR8—C(═O)—C1-6alkyl-C(═O)—OR4, —NR8—C1-6alkyl-OR4, —NR8—C1-6alkyl-NR6R7, —NR8—C1-6alkyl-imidazolyl, —NR8—SO2R9, —N═CH—NR6R7, —NH—C(═NH)—NH2, —SO2NR6R7, and —O—PO(OR8)2;D forms pyridine, pyrimidine, pyrazine, pyridazine, pyrrole, imidazole, pyrazole, furane, oxazole, isoxazole, thiophene, thiazole, and isothiazole;R2is C1-6alkyl, polyhaloC1-6alkyl, halo, cyano, —COOR4, —OR4, and —NR6R7;R3is phenyl, pyridyl, pyrimidinyl, imidazopyridyl, pyrazolopyridyl, triazolopyridyl, quinoline, imidazopyrimidinyl, pyrazolopyrimidinyl, triazolopyrimidinyl, pyridopyrimidinyl; which may optionally be substituted;m is 0, 1, 2 or 3; n is 0, 1, 2 or 3;pharmaceutical compositions containing these compounds, methods for preparing these compounds and compositions.

REFERENCES:
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