HIV envelope polynucleotides and immunogenic composition

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

Reexamination Certificate

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C424S184100, C424S185100, C424S188100, C424S202100, C424S204100, C424S208100, C514S04400A, C536S023100, C536S023400

Reexamination Certificate

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07071322

ABSTRACT:
Oligonucleotide sequences encoding gp120 polypeptides from breakthrough isolates of vaccine trials using MN-rgp120 and the encoded gp120 polypeptides are provided. Use of the gp120 polypeptides from one or more of the isolates in a subunit vaccine, usually together with MN-rgp120, can provide protection against HIV strains that are sufficiently different from the vaccine strain (e.g.; MN-rgp120) that the vaccine does not confer protection against those strains. Antibodies induced by the polypeptides are also provided.

REFERENCES:
patent: 4725669 (1988-02-01), Essex et al.
patent: 5166050 (1992-11-01), Shriver et al.
patent: 5420030 (1995-05-01), Reitz, Jr. et al.
patent: 5576000 (1996-11-01), Reitz, Jr. et al.
patent: 5792459 (1998-08-01), Haigwood
patent: A-33320/89 (1989-11-01), None
patent: 0 187 041 (1986-07-01), None
patent: 0 327 180 (1989-08-01), None
patent: 0 335 635 (1989-10-01), None
patent: 0 339 504 (1989-11-01), None
patent: 0 527 760 (1993-02-01), None
patent: 0 394 386 (1995-09-01), None
patent: 0 187 041 (1996-05-01), None
patent: 0 279 688 (1997-04-01), None
patent: WO 89/12095 (1989-12-01), None
patent: WO 90/02196 (1990-03-01), None
patent: WO 90/03984 (1990-04-01), None
patent: WO 91/04273 (1991-04-01), None
patent: WO 91/13906 (1991-09-01), None
patent: WO 91/15238 (1991-10-01), None
patent: WO 91/15512 (1991-10-01), None
patent: WO 93/20104 (1993-10-01), None
patent: WO 94/28929 (1994-12-01), None
Butini, et al.; Comparative analysis of HIV-specific CTL activity in lymphoid tissue and peripheral blood; J. Cellular Biochemistry; Supp. 18B J 306.
Baltimore, et al.; HIV vaccines: prospects and challenges; Scientific American; pp. 98-103.
Berkower, et al., “A Predominant Group-Specific Neutralizing Epitope of Human Immunodeficiency Virus Type 1 Maps to Residues 342 to 511 of the Envelope Glycoprotein gp120,” Journal of Virology 65 (13), pp. 5983-5990 (Nov. 1991).
Bhat, S. et al., “The Galactosyl Ceramide/Sulfatide Receptor Binding Region of HIV-1 gp120 Maps to Amino Acids 206-275,” AIDS Research and Human Retroviruses 9:2:175-181 (XP002139997) (Feb. 1993).
Cohen; Jitters jeopardize AIDS vaccine trial; Science; vol. 262; pp. 980-981.
Fox; No winners against AIDS; Bio/Technology; vol. 12, p. 128.
Fung, et al., “Identification and Characterization of a Neutralization Site within the Second Variable Region of Human Immunodeficiency Virus Type 1 gp120,” Journal of Virology 66(2), pp. 848-856 (Feb. 1992).
Haynes et al.; Update on the issues of HIV vaccine development; Ann. Med.; vol. 28; pp. 39-41.
Haynes; Scientific and social issues of human immunodeficiency virus vaccine development; Science; vol. 260; pp. 1279-1286.
Ho et al., “Another discontinuous epitope on glycoprotein gp120 that is important in human immunodeficiency virus type 1 neutralization is identified by a monoclonal antibody,” Proc. Natl. Acad. Sci. USA 88, pp. 8949-8952 (Oct. 1991).
Kahn, et al., Clinical, immunologic, and virologic observations related to human immunodeficiency virus (HIV) type 1 infection in a volunteer in an HIV-1 vaccine clinical trial. Journal of Infectious Diseases (May 1995) vol. 171, pp. 1343-1350.
McCutchan, et al; Genetic variants of HIV-1 Thailand; AIDS Research and Human Retroviruses; vol. 8, No. 11; pp. 1887-1896.
Moore, et al., “Immunochemical Analysis of the gp120 Surface Glycoprotein of Human Immunodeficiency Virus Type 1: Probing the Structure of the C4 and V4 Domains and the Interaction of the C4 Domain with the V3 Loop,” Journal of Virology 67(8), pp. 4785-4796 (Aug. 1993).
Moore, et al., “Probing the Structure of the Human Immunodeficiency Virus Type 1 Surface Glycoprotein gp120 with a Panel of Eight Monoclonal Antibodies,” Journal of Virology 68(1) pp. 469-484 (Jan. 1994).
Moore, et al., “Probing the Structure of the V2 Domain of Human Immunodeficiency Virus Type 1 Surface Glycoprotein gp120 with a Panel of Eight Monoclonal Antibodies: Human Immune Response to the V1 and V2 Domains,” Journal of Virology 67(10), pp. 6136-6151 (Oct. 1993).
Sirko, et al. Genotype and phenotype characterization of a neutralization-resistant breakthrough population of HIV-1, Virology (1996) pp. 238-242.
Sullivan, et al., “Effect of Amino Acid Changes in the V1/V2 Region of the Human Immunodeficiency Virus Type 1 gp120 Glycoprotein on Subunit Assocation, Syncytium Formation, and Recognition by a Neutralizing Antibody,” Journal of Virology 67(6), pp. 3674-3679 (Jun. 1993).
Zarling, et al.; T-cell responses to human AIDS virus in macaques immunized with recombinant vaccinia viruses; Nature; vol., 323; pp. 344-346.
Allan et al., “Major Glycoprotein Antigens that Induce Antibodies in AIDS Patients are Encoded by HTLV-III,”Science228, pp. 1091-1094 (May 31, 1985).
Anderson et al., “Effect of Dose and Immunization Schedule on Immune Response of Baboons to Recombinant Glycoprotein 120 of HIV-1,”The Journal of Infectious Diseases160(6), pp. 960-969 (Dec. 1989).
Arthur et al., “Challenge of Chimpanzees (Pan troglodytes) Immunized with Human Immunodeficiency Virus Envelope Glycoprotein gp 120,”Journal of Virology63(12), pp. 5046-5053 (Dec. 1989).
Arthur, Larry O., “Serological Responses in Chimpanzees Inoculated With Human Immunodeficiency Virus Glycoprotein (gp120) Subunit Vaccine,”Proc. Natl. Acad. Sci. USA84, pp. 8583-8587 (Dec. 1987).
Barin et al., “Virus Envelope Protein of HTLV-III Represents Major Target Antigen For Antibodies in AIDS Patients,”Science228, pp. 1094-1096 (May 31, 1985).
Barrett et al., “Large-Scale Production and Purification of a Vaccinia Recombinant-Derived HIV-1 gp160 and Analysis of Its Immunogenicity,”AIDS Research And Human Retroviruses5(2), pp. 159-171 (1989).
Berman et al., “Protection from Genital Herpes Simplex Virus Type 2 Infection by Vaccination with Cloned Type 1 Glycoprotein D,”Science227, pp. 1490-1492 (Mar. 1985).
Berman et al., “Human Immunodeficiency Virus Type 1 Challenge of Chimpanzees Immunized with Recombinant Envelope Glycoprotein gp120,”Proc. Natl. Acad. Sci. USA85, pp. 5200-5204 (Jul. 1988).
Berman et al., “Expression and Immunogenicity of the Extracellular Domain of the Human Immunodeficiency Virus Type-1 Envelope Glycoprotein gp160,”Journal of Virology63(8), pp. 3489-3498 (Aug. 1989).
Berman, P., et al., “Protection of Chimpanzees From Infection by HIV-1 After Vaccination with Recombinant Glycoprotein gp120 But Not gp160,”Nature345(6276), pp. 622-625 (Jun. 14, 1990).
Berman, P., et al., “Neutralization of Multiple Laboratory and Clinical Isolates of Human Immunodeficiency Virus Type 1 (HIV-1) by Antisera Raised Against gp120 from the MN Isolate of HIV-1,”Journal of Virology66(7), pp. 4464-4469 (Jul. 1992).
Berman et al., “Genetic and Immunologic Characterization of Viruses Infecting MN-rgp120 Vaccinated Volunteers,”One World, One Hope: XI International Conference on AIDS, 10:3:10 (Jul. 7-12, 1996).
Berman et al., “Genetic and Immunologic Characterization of Viruses Infecting MN-rpg120-Vaccinated Volunteers,” The Journal of Infectious Disease, 176:2:384-397 (Aug. 1997).
Broliden, P., et al., “Identification of Human Neutralization-inducing Regions of the Human Immunodeficiency Virus Type I Envelope Glycoproteins,”Proc. Natl. Acad. Sci. USA89, pp. 461-465 (Jan. 1992).
Bruck, Claudine, et al., “HIV-1 Envelope-elicited Neutralizing Antibody Titres Correlate With Protection and Virus Load In Chimpanzees,”Vaccine12(12), pp. 1141-1148 (1994).
Chakrabarti et al., “Expression of the HTLV-III Envelope Gene by a Recombinant Vaccinia Virus,”Nature320, pp. 535-540 (Apr. 10, 1986).
Clements et al., “The V3 Loops of the HIV-1 and HIV-2 Surface Glycoproteins Contain Proteolytic Cleavage Sites: A Possible Functions in Viral Fusion?”AIDS Research and Human Retroviruses7(1), pp. 3-16 (1991).
Clements,Certificate of

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