HIV coreceptor mutants

Details HIV coreceptor mutants HIV coreceptor mutants

1997-08-08

2000-05-02

Budens, Robert D.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 5, 435 912, 435 9121, 436501, 436504, 536 231, 536 235, C12Q 168, C12Q 170

Patent

active

060571020

ABSTRACT:
Entry of HIV-1 into target cells requires cell surface CD4 as well as additional host cell cofactors. A cofactor required for infection with virus adapted for growth in transformed T cell lines was recently identified and named fusin. Fusin, however, does not promote entry of macrophage-tropic viruses that are believed to be the key pathogenic strains in vivo. It has now been determined that the principal cofactor for entry mediated by the envelope glycoproteins of primary macrophage-tropic strains of HIV-1 is CC-CKR5, a receptor for the .beta.-chemokines RANTES, MIP-1.alpha., and MIP-1.beta.. It has also been found that individuals who are homozygous for a mutation of the CKR-5 receptor are resistent to HIV infection; in vitro infection requires a 1000-fold higher dose of HIV than normal cells. The mutation results in complete suppression of CKR-5 expression.

REFERENCES:
patent: 5399346 (1995-03-01), Anderson et al.
Feng et al., Science 272: 872-877, May 10, 1996.
Deng et al., Nature 381: 661-666, Jun. 20, 1996.
Dragic et al., Nature 381:667-673, Jun. 20, 1996.
Alkhatib et al., Science 272:1955-1958, Jun. 28, 1996.
Choe et al., Cell 85: 1135-1148, Jun. 28, 1996.
Doranz et al., Cell 85: 1149-1158, Jun. 28, 1996.
Liu et al., Cell 86: 367-377, Aug. 9, 1996.
Alkhatib (1996) Science 272:1955-8.
Baggiolini et al(1995) Int J Immunopharmacol 17:103-8.
Bates et al. (1996) Cell 86:1-3.
Bedinger et al(1988) Nature 334:162-5.
Benton and Davis(1977) Science 196:180.
Cao et al N Engl J Med 332:201-8.
Cech(1988) J Am Med Assoc 260:3030.
Chou (1996) Cell 85:1135-48.
Cocchi et al(1996) Science 720:1811-5.
Combadiere et al., DNA Cell. Biol. 14:673-680 (1995).
Connor et al (1995) Virol 206:936-44.
Deng et al(1996) Nature 381:661-6.
Dimitrov(1996) Nature Medicine 2:640-1.
Doranz (1996) Cell 85:1149-58.
Dragic et al(1996) Nature 381:667-73.
Feng et al(1996) Science 272:872-7.
Field et al(1988) Molec Cell Biol 8:2159-65.
Fodor et al(1991) Science 251:767-73.
Geysen et al(1986) Mole Immunol 23:709-15.
Goodson(1984) in: Medical Applications of Controlled ReleaseLanger and Wise eds., CRC Press: Boca Raton, Florida, Chapter 6, pp. 115-138.
Hanks et al(1995) Science 269:679-82.
He and Landau(1995) J Virol 69:4587-92.
Higuchi(1989) in PCR Technology: Principles and Applications for DNA Amplification, Erlich ed, Stockton Press:61-70.
Horuk, Trends Pharmacol. Sci. 15:159-65 (1994).
Horuk et al(1993) Science 261:1182-4.
Hutchinson et al(1978) J Biol Chem 253:6551.
Kaplitt et al(1991) Molec Cell Neurosci 2:320-30.
Killeen et al. (1993) EMBO J. 12:1547-53.
Landau and Littman (1988) Nature 334:159-62.
Landau and Littman (1992) J Virol 66:5110-3.
Landau et al (1991) J Virol 65:162-9.
Langer and Peppas(1983) J Macromol Sci Rev Macromol Chem 23:61-126.
Langer(1990) Science 249:1527-33.
Lenburg and Landau(1993) J Virol 67:7238-45.
Liu et al. (1996) Cell 86:367-77.
Locke et al(1988) Somat Cell Mol Genet 19:95-101.
Lusso, P. (1997) Nature Med. 3:1074-5.
MacDonald et al., Nature Genet. 1:99-103 (1992).
MacDonald et al(1991) Am J Hum Genet 49:723-34.
Mallinson et al(1995) Br J Haematol 90:823-9.
Marcus-Sekura(1988) Anal Bioche 172:289-95.
Morgenstern and Land(1990) Nucl Acid Res 18:3587-96.
Naylor et al(1996) Cell Genet 72:90-4.
Needles et al(1993)Proc Natl Aca Sci USA 90:10700-4.
Neote et al(1993) Cell 72:415-25.
Ohlmeyer et al(1993) Proc Natl Aca Sci USA 90:10922-6.
Page et al(1990) J Virol 64:5270-6.
Pantaleo et al., N. Engl. J. Med. 332:209-216 (1995).
Paxton et al(1996) Nat Med 2:412-7.
Paxton et al(1993) J Virol 67:7229-37.
Raport et al., Gene 163:295-9 (1995).
Rowland-Jones et al(1995) Nat Med 1:59-64.
Samson et al(1996) Biochemistry 35:3362-7.
Samulski et al(1987) J Virol 61:3096-101.
Sattentau and Weiss, Cell 52:631-633 (1988).
Schall, Cytokine 3:165-183 (1991).
Scott and Smith(1990) Science 249:386-90.
Spira and Ho(1995) J Virol 69:422-9.
Stratford-Perricauder et al(1992) J Clin Invest 90:626-30.
Wilson et al. (1992) J. Biol. Chem. 267:963-7.
Wu et al(1992) J Biol Chem 267:963-7.

Affiliated with

Also associated with

Rating

HIV coreceptor mutants does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with HIV coreceptor mutants, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and HIV coreceptor mutants will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1592714