Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1989-05-25
1993-05-04
Nucker, Christine M.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
530375, 435974, 435975, C07K 1500
Patent
active
052083217
ABSTRACT:
Characterization of the envelope transmembrane protein of human immunodeficiency virus type 2 (HIV-2) was carried out using murine polyclonal and monoclonal antibodies or patient sera specific for HIV-2 proteins. A 80-Mr glycoprotein (gp80) was produced in HIV-2 infected cells along with three other glycoproteins that were recently reported: the extracellular glycoprotein (gp125), the envelope glycoprotein precursor (gp140), and the transient dimeric form of gp140 (gp300). The gp125 and gp80 were detectable after the synthesis of gp140 and the formation of gp300. Among these four glycoproteins, only gp80 and gp125 were associated with HIV-2 virions. As the other glycoproteins, gp80 was recognized by all HIV-2 positive sera. A murine polyclonal antibody raised against the purified gp300 recognized all four glycoproteins. On the other hand, a monoclonal antibody raised against a synthetic polypeptide deduced from the sequence of the transmembrane glycoprotein of HIV-2, recognized gp140, gp300 and gp80; thus indicating that gp80 should be related to the transmembrane protein of the envelope. Dimerization of envelope glycoprotein precursor and the transmembrane glycoprotein was also observed in cells infected with simian immunodeficiency virus (SIV), a virus closely related to HIV-2. Dimerization of the envelope precursors might be essential for the processing of these glycoproteins into the mature products, extracellular and transmembrane glycoproteins. Furthermore, the dimeric form of the transmembrane glycoproteins might be important for the optimal structure of the virus and thus for its infectivity.
REFERENCES:
patent: 4839288 (1989-06-01), Montagmier et al.
Veronese et al, "Identification of Simian Immunodeficiency Virus SIV.sub.MAC env Gene Products", J. Virology, vol. 63(3):1416-1419 (1989).
Hovanessian Ara G.
Krust Bernard
Laurent Anne G.
Montagnier Luc
Rey Marie-Anne
Institut Pasteur
Nucker Christine M.
Stucker Jeffrey
LandOfFree
HIV-2 transmembrane glycoprotein homodimer (GP 80) does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with HIV-2 transmembrane glycoprotein homodimer (GP 80), we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and HIV-2 transmembrane glycoprotein homodimer (GP 80) will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1975981