HIV-1 VPR interactions with mitochondrial apoptosis inducing...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

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C435S007800, C530S300000, C530S388400, C424S009100

Reexamination Certificate

active

07598041

ABSTRACT:
Assays to identify Vpr/AIF interaction and translocation inhibitors are disclosed.

REFERENCES:
patent: 5780220 (1998-07-01), Weiner et al.
patent: 5976786 (1999-11-01), Finkel et al.
patent: 6060587 (2000-05-01), Weiner et al.
patent: WO94/19456 (1994-09-01), None
patent: WO98/35234 (1998-08-01), None
Zhao et al. “Yeast Perspectives on HIV-1 VPR” Frontiers in Bioscience vol. 5, (Dec. 1, 2000) pp. 905-916.
Jacotot E. et al. “The HIV-1 viral protein R induces apoptosis via a direct effect on the mitochondrial permeability transition pore”. J Exp Med. Jan. 3, 2000;191(1):33-45.
Daugas E. et al. “Apoptosis-inducing fctor (AIF): a ubiquitous mitochondrial oxidoreductase involved in apoptosis”. FEBS Lett. Jul. 7, 2000;476(3):118-23. Review.
Susin SA et al. “Molecular characterization of mitochondrial apoptosis-inducing factor”. Nature. Feb. 4, 1999;397(6718):441-6.
Kino T et al. “Partner molecules of accessory protein Vpr of the human immunodeficiency virus type 1”, DNA and Cell Biology, 23(4):193-205, 2004.
Genini, et al., “HIV Induces lymphocyte apoptosis by a p53-initiated, mitochondrial-mediated mechanism,” FASEB J. (2001) 15:5-6.
Ferri, et al., “Mitochondrial control of cell death induced by HIV-1 encoded proteins,” Ann. NY Acad. Sci. (2000) 926:149-164.
Ferri, et al., “Apoptosis control in syncytia induced by the HIV type-1 envelope glycoprotein complex: role of mitochondria and caspases,” J. Exp. Med. (2000) 192:1081-1092.
T. Roumier et al., “The C-Terminal Moiety of HIV-1 Vpr Induces Cell Death via a Caspase-Independent Mitochondrial Pathway”, Cell Death and Differentiation, 2002; 9(11):1212-1219.

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