Chemistry: molecular biology and microbiology – Treatment of micro-organisms or enzymes with electrical or... – Modification of viruses
Patent
1995-12-14
1998-11-17
Railey, II, Johnny F.
Chemistry: molecular biology and microbiology
Treatment of micro-organisms or enzymes with electrical or...
Modification of viruses
424 932, 4353201, C12N 1586, C12N 510, C12N 1564, C12N 1549
Patent
active
058375120
ABSTRACT:
The present invention pertains to a genetically altered human immunodeficiency virus type 1 (HIV-1) which replicates only in human CD4+ cells that express the Tax protein of Human T-cell Lymphotropic Virus Type I (HTLV-I), wherein the HIV long terminal repeat (LTR) promoter and enhancer sequences (NF-kappa-B and Sp1 binding sites) of the genetically altered human immunodeficiency virus type 1 have been replaced by two copies of the HTLV-I LTR 21 base pair repeat Tax-responsive element (TRE). The present invention also pertains to methods for killing HTLV-1 infected cells in humans with HTLV-1 disease (HTLV-1 tumors and HAM/TSP) with the novel genetically altered human immunodeficiency virus type 1 (HIV-1).
REFERENCES:
"Report and Recommendations of the Panel to Assess the NIH Investment in Research on Gene Therapy," Orkin and Motulsky, Co-chairs, Dec. 7, 1995.
Sutton, The Lancet 337:1553 (1991).
Johnston et al., Science 260:1286-1293 (1993).
Lu et al., Journal of Virology 63(9):4115-4119 (1989).
Marshall Science 269:1050-1055 (1995).
Bodkin Marion
Lin Hsin-Ching
Rabson Arnold B.
Strair Roger
Muccino Richard R.
Railey II Johnny F.
University of Medicine & Dentistry of NJ
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