Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Glycoprotein – e.g. – mucins – proteoglycans – etc.
Patent
1993-03-26
1999-02-09
Smith, Lynette F.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Glycoprotein, e.g., mucins, proteoglycans, etc.
530350, 536 231, 4241881, 4241841, 4242041, 4242081, C07K 100, C07K 1400, A61K 3921, A61K 3912
Patent
active
058696245
ABSTRACT:
The subject invention provides a recombinant nucleic acid molecule which encodes a mutant HIV-1 gp120 envelope glycoprotein comprising a V3 loop deletion and a C4 domain.sub.(W.fwdarw.X) point mutation wherein X is an amino acid residue other than tryptophan, and the HIV-1 gp120 envelope glycoprotein encoded thereby.
The subject invention further provides a method of obtaining partially purified antibodies which specifically bind to the CD4-binding domain of HIV-1 gp120 envelope glycoprotein, the partially purified antibodies produced thereby, and pharmaceutical compositions comprising same. Finally, the subject invention provides methods of treating HIV-1-infected subjects, and of reducing the likelihood of HIV-1-exposed and non-HIV-1-exposed subjects' becoming infected with HIV-1 using the pharmaceutical compositions of the subject invention.
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Wyatt, et al, 1992, "Relationship of the human . . . " Journal of Virology, vol. 66, No. 12: 6997-7004.
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Cohen, 1993, "Jitters Jeopardize AIDS Vaccine Trials" Science 262:980-981.
Hasel Karl W.
Maddon Paul J.
Progenics Pharmaceuticals Inc.
Smith Lynette F.
White John P.
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