HIV-1 protease inhibitors

Details HIV-1 protease inhibitors HIV-1 protease inhibitors

1996-06-20

1998-10-27

Tsang, Cecilia J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

560 25, 560 26, 546265, 548328, C07K 1900

Patent

active

058278273

ABSTRACT:
A series of novel oxirane derivatives, which are useful for inhibiting HIV are disclosed. Particularly of value are peptidomimetic compounds, containing a terminal epoxide group on a peptide or psuedopeptide backbone, which are believed to inhibit HIV protease by extruding enzyme-bound water molecules from the active site of the enzyme.

REFERENCES:
patent: 5142056 (1992-08-01), Kempe et al.
Rich et al., "Effect of Hydroxl in Hydroxethylamine Dipepetide Isosteres On HIV Proteasew Inhibition"S. Med. Chem., (1991) v.34 pp. 1222-1225.

Affiliated with

Also associated with

Rating

HIV-1 protease inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with HIV-1 protease inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and HIV-1 protease inhibitors will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1613937