HIV-1 prophylactic composition and method

Details HIV-1 prophylactic composition and method HIV-1 prophylactic composition and method

1995-06-07

1999-04-06

Adams, Donald E.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Virus or component thereof

424 161, 4242801, 4241601, 4241931, A61K 3921, A61K 5100, A61K 3942, A61K 39385

Patent

active

058914447

ABSTRACT:
A composition and method for inducing a protective immune response to HIV-1 in an individual, of (a) a replication incompetent HIV-1, HIV-1 pseudovirus, HIV-1 VLP or oligomeric gp120; and (b) a water soluble polyphosphazene polyelectrolyte, wherein (a) and (b) are present in an amount effective to induce a protective immune response against HIV-1.

REFERENCES:
patent: 5494673 (1996-02-01), Andrianov et al.
Fahey et al., Status of immune-based therapies in HIV infection and AIDS, Clin. exp. Immunol. 88, 1-5, see entire document, 1992.
Fox, No winners against AIDS, Bio/Technology, vol. 12, p. 128, 1994.
Cohen et al., Ionically Cross-Linkable Polyphosphazene: A Novel Polymer for Microencapsulation, J. Am. Chem. Soc., 112, 7832-7833, see p. 7833, column 1, paragraph 1, 1990.
Sodroski et al., Molecular analysis of single cell lysis by HIV-1, Int. Conf. AIDS (Canada), Jun. 4-9, 5 p. 513, see Abstract, 1989.

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