HIV-1 gag cytotoxic T-lymphocyte epitope and method of use

Details HIV-1 gag cytotoxic T-lymphocyte epitope and method of use HIV-1 gag cytotoxic T-lymphocyte epitope and method of use

1994-12-19

1997-12-23

Adams, Donald E.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving virus or bacteriophage

435 724, 530326, 530300, 4241881, C12Q 170, G01N 3353, G01N 33555, A61K 3800

Patent

active

057006350

ABSTRACT:
A novel human immunodeficiency virus type 1 (HIV-1) cytotoxic T-lymphocyte (CTL) epitope has been identified in the gag coding region. This epitope corresponds to amino acids 255-269 of Gag and has the following sequence: NH.sub.2 -asn-pro-pro-ile-pro-val-gly-glu-ile-tyr-lys-arg-trp-ile-ile-COOH. This peptide interacts specifically with human leukocyte antigen-B8 (HLA-B8). This peptide is useful for the identification HIV-1 gag-specific CTL.

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