HIV-1 envelope protein associated with a broadly reactive...

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Amino acid sequence disclosed in whole or in part; or...

Reexamination Certificate

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C424S199100, C424S204100, C530S300000, C530S350000, C530S327000, C530S826000

Reexamination Certificate

active

07090848

ABSTRACT:
The present invention relates to HIV-1 envelope proteins from a donor with non-progressive HIV-1 infection whose serum contains broadly cross-reactive, primary virus neutralizing antibody. The invention also relates to isolated or purified proteins and protein fragments that share certain amino acids at particular positions with the foregoing HIV-1 proteins.

REFERENCES:
patent: 4943627 (1990-07-01), Gilbert et al.
patent: 5019387 (1991-05-01), Haynes et al.
patent: 5439809 (1995-08-01), Haynes et al.
patent: 5459060 (1995-10-01), Cotropia
patent: 5622933 (1997-04-01), Sabatier et al.
patent: 5756674 (1998-05-01), Katinger et al.
patent: 5854400 (1998-12-01), Chang et al.
patent: 5993819 (1999-11-01), Haynes et al.
patent: 0471407 (1992-02-01), None
patent: WO 92/20373 (1992-11-01), None
patent: WO 93/05812 (1993-04-01), None
Sequence alignment of SEQ ID No. 1 with Sala et al. SPTREMBL—17; Accession No. Q78039; Nov. 1996; from J. Virol.; 68: 5280-5283.
Sequence alignment of SEQ ID No. 1 with Lukashov et al. SPTREMBL—17 database; Accession No. Q69692; 1996; from AIDS Research and Human Retroviruses; 12: 951-953.
Sala et al. Journal of Virology. 1994; 68 (8): 5280-5283.
Lukashov et al. AIDS Research and Human Retroviruses. 1996; 12 (10): 951-953.
Kelleher et al. AIDS Research and Human Retroviruses. 1997; 13 (1): 29-32.
Korber et al. British Medical Bulletin. 2001; 58: 19-42.
Sala et al. Journal of Virology. 1994; 68 (8): 5280-5283.
Sequence alignment of SEQ IN No. 1 with Sala et al. SPTREMBL—21; Accession No. Q78039; Nov. 1996; from J. Virol.; 68: 5280-5283.
Lukashov et al. (SPTREMBL—17 database; Accession No. Q69692; 1996; from AIDS Research and Human Retrovirusus; 12: 951-953.
Korber et al. (British Medical Bulletin. 2001; 58: 19-42.
Kelleher et al. AIDS Research and Human Retroviruses. 1997; 13 (1): 29-32.
Klein et al. Clinical Therapeutics. 2000; 22 (3): 295-314) on pp. 304-305.
Lukashov et al. AIDS Research and Human Retroviruses. 1996; 12 (10): 951-953.
Sequence alignment of SEQ ID No. 24 with geneseq database accession No. AAR77770, submitted Sep. 1995 in WO 94/229339-A1.
Sequence alignment of SEQ ID No. 24 with SPTREMBL database accession No. Q71538 submitted Nov. 1, 1996 by Strunnikova et al.
Sequence alignment of the V3 region of SEQ ID No. 1 to Geneseq database accession No. AAR20883, submitted Jun. 1, 1992 in EP471407-A of Lewis et al.
Cotropia et al. (1996) A human monoclonal antibody to HIV-1 gp41 with neutralizing activity against diverse laboratory isolates, J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 12:221-232.
Hioe et al. (1997) Neutralization of HIV-1 primary isolates by polyclonal and monoclonal human antibodies, Int. Immunol. 9:1281-1290.
Moore et al. (1993) Probing the structure of the V2 domain of human immunodeficiency virus type 1 surface glycoprotein gp120 with a panel of eight monoclonal antibodies: Human immune response to the V1 and V2 domains, J. Virol. 67:6136-6151.
Muster et al. (1993) A conserved neutralization epitope on gp41 of human immunodeficiency virus type 1, J. Virol. 67:6642-6647.
Sabri et al. (1996) Lack of correlation between V3 amino acid sequence and syncytium-inducing capacity of some HIV type 1 isolates, AIDS Res. Hum. Retroviruses, 12:855-858.
Thali et al. (1993) Characterization of conserved human immunodeficiency virus type-1 gp120 neutralization epitopes exposed upon gp120-CD4, J. Virol. 67:3978-3988.
Thali et al. (1994) Resistance to neutralization by broadly reactive antibodies to the human immunodeficiency virus type-1 gp120 glycoprotein conferred by a gp41 amino acid change, J. Virol. 68:674-680.
Trkola et al. (1996) Human monoclonal antibody 2G12 defines a distinctive neutralization epitope of human immunodeficiency virus type-1, J. Virol. 70:1100-1108.
VanCott et al. (1997) Antibodies with specificity to native gp120 and neutralization activity against primary human immunodeficiency virus type-1 isolates elicited by immunization with oligomeric gp160, J. Virol. 71:4319-4330.
Zwart et al. (1991) Immunodominance and antigenic variation of the principal neutralization domain of HIV-1, J. Virol. 181:481-489.
XP002220280, EBI database accession No. O71260, Database EMBL Online, (1998).
XP002220281, EBI database accession No. P88523, Database EMBL Online, (1997).
XP002220282, EBI database accession No. Q73297, Database EMBL Online, (1996).
Douglas et al. (1996) An efficient method for the rescue and analysis of functional HIV-1 env genes: evidence for recombination in the vicinity of the tat/rev splice site, AIDS 10:39-46.
Purtscher et al. (1994) A broadly neutralizing human monoclonal antibody against gp41 of human immunodeficiency virus type 1, AIDS Res. Hum. Retroviruses 10:1651-1658.
Trkola et al. (1995) Cross-clade neutralization of primary isolates of human immunodeficiency virus type 1 by human monoclonal antibodies and tetrameric CD4-IgG, J. Virol. 69:6609-6617.

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