Histoplasma capsulatum catalase sequences and their use in...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

Reexamination Certificate

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C435S091100, C435S091200, C536S023100, C536S023700, C536S024100, C536S024300, C536S024320

Reexamination Certificate

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07052837

ABSTRACT:
The present invention describesHistoplasmosis capsulatumcatalase A and catalase P nucleic acid and protein sequences as reagents for the detection ofH. capsulatuminfection. Specifically, the invention describes intron sequences from theH. capsulatumcatalase A (CATA) and catalase P (CATP) genes which can be used for hybridization and PCR based detection ofH. capsulatuminfection. In another embodiment, assays forH. capsulatumcatalase P or catalase A polypeptides are used as diagnostic tests forH. capsulatuminfection and histoplasmosis, respectively. Also described is the differentiation ofH. capsulatumfromBlastomyces dermititidisbased on aH. capsulatumcatalase P PCR based assay.

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GenBank Accession AL449104.
Sequence alignments.
GenBank Accession AC036149, M88342.
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