Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Fusion protein or fusion polypeptide
Patent
1999-07-14
2000-10-24
Achutamurthy, Ponnathapu
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Fusion protein or fusion polypeptide
435 691, 4352523, 4353201, 536 231, 536 234, 536 235, 530350, C12P 2106, C12N 120, C12N 1500, C07H 2104, C07K 100
Patent
active
061363146
ABSTRACT:
The present invention provides a human histone fusion protein (HFP) and polynucleotides which identify and encode HFP. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. In addition, the invention also provides methods for producing HFP and for treating or preventing disorders associated with expression of HFP.
REFERENCES:
Goldknopf, I.L., et al., "Isopeptide linkage between nonhistone and histone 2A polypep tides of chromosomal conjugate-protein A24", Proc Natl Acad Sci USA, 74(3) : 864-868 (1977).
Palmer, D.K., et al., "Purification of the centromere-specific protein CENP-A and demonstration that it is a distinctive histone", Proc Natl Acad Sci USA, 88 (9) : 3734-3738 (1991).
Pehrson, J.R. et al., "MacroH2A, a Core Histone Containing a Large Nonhistone Region", Science, 257: 1398-1400 (1992).
Pehrson, J.R., et al., (GI 205275) GenBank Sequence Database (Accession M99065) National Center for Biotechnology Informatiion: National Library of Medicine, Bethesada, Maryland 20849 (205276).
Dobner, T., et al., "A novel divergently transcribed human histone H2A/H2B gene pair", DNA Seq, 1 (6) : 409-413 (1991).
Constanzi, C. And Pehrson, J.R. (GI 1711126), GenBank Sequence Database (Accession U79139), National Center for Biotechnology Information, National LIbrary of Medicine, Bethesda, Maryland 20894.
Goli Surya K.
Hillman Jennifer L.
Achutamurthy Ponnathapu
Incyte Pharmaceuticals Inc.
Saidha Tekchand
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