Organic compounds -- part of the class 532-570 series – Organic compounds – Hydroxamic acids – chalcogen analogs or salts thereof
Reexamination Certificate
2011-08-09
2011-08-09
Kumar, Shailendra (Department: 1621)
Organic compounds -- part of the class 532-570 series
Organic compounds
Hydroxamic acids, chalcogen analogs or salts thereof
C514S575000
Reexamination Certificate
active
07994362
ABSTRACT:
The present invention concerns the discovery that proteins encoded by a family of genes, termed here HDx-related genes, which are involved in the control of chromatin structure and, thus in transcription and translation. The present invention makes available compositions and methods that can be utilized, for example to control cell proliferation and differentiation in vitro and in vivo.
REFERENCES:
patent: 4820828 (1989-04-01), Demers et al.
patent: 5659016 (1997-08-01), Nakamura et al.
patent: 5700811 (1997-12-01), Breslow et al.
patent: 5763182 (1998-06-01), Nakamura et al.
patent: 6030945 (2000-02-01), Ashkenazi
patent: 6428960 (2002-08-01), Clark et al.
patent: 6777217 (2004-08-01), Schreiber et al.
patent: 7250504 (2007-07-01), Grozinger et al.
patent: 2003/0129724 (2003-07-01), Grozinger et al.
patent: 2004/0092598 (2004-05-01), Watkins et al.
patent: 2005/0287629 (2005-12-01), Grozinger et al.
patent: 2006/0079528 (2006-04-01), Finn et al.
patent: 2007/0093413 (2007-04-01), Schreiber et al.
patent: 2009/0036318 (2009-02-01), Grozinger et al.
patent: 0 323 590 (1989-07-01), None
patent: 331524 (1989-09-01), None
patent: 0708112 (1996-04-01), None
patent: WO 97/11366 (1997-03-01), None
patent: WO 98/47869 (1998-10-01), None
International Search Report and Written Opinion for PCT/US2009/004235 mailed Mar. 4, 2010.
Adams etal., “Initial assessment of human gene diveristy and expression patterns based upon 83 million nuclotides of cDNA sequence”, Nature, 1995, 377 (suppl.) 3-175.
Aparicio et al., “Modifiers of position effect are shared between telomeric and silent mating-type loci inS. cerevisiae”, cell, 1991, 66, 1279-1287.
Auffray et al., “IMAGA: molecular integration of the analysis of the human genome and its expression”, C.R. Acad. Sci. III, Sci. Vie, 1995, 318(2), 260-272.
Baer et al., “Eukaryotic RNA polymerase II binds to nucleosome cores from transcribed genes”, Nature, 1983, 301, 482-488.
Bowdish et al., “Analysis of RIM11, a yeast protein kinase that phosphorylates the meiotic activator IME1”, Mol. Cell. Biol.Dec. 1994;14(12):7909-19.
Braunstein et al., “Transcriptional silencing in yeast is associated with reduced nucleosome acetylation”, Genes Dev. 1993, 7, 592-604.
Carmen et al., “HDA1 and HDA3 Are Components of a Yeast Histone Daecetylase (HAD) Complex”, J. Bio. Chem. 1996, 271, 15837-15844.
Cavenee et al., Expression of recessive alleles by chromosomal mechanisms in retinoblastoma, Nature, 1983, 305, 774-784.
Clipstone et al., “Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation”, Nature, 1992, 357, 695-697.
Csordas et al. “On the biological role of histone acetylation”, Biochem. J. 1990, 265, 23-38.
Davie et al., “Multiple functions of dynamic histone acetylation”, J. Cell. Biochem. 1994, 55, 98.
Felsenfeld, “Chromatin as an essential part of the transcriptional mechanism”, Nature, 1992, 355, 219.
Fleming et al., “The total synthesis of (±)-trichostatin A : Some observations on the acylation and alkylation of silyl enol ethers, silyl dienol ethers and a silyl trienol ether”, Tetrahedron, 1983, 39, 841-846.
Friend et la. “Deletions of a DNA sequence in retinoblastomas and mesenchymal tumors: organization of the sequence and its encoded protein”, PNAS, 1987, 84, 9059-9063.
Furukawa et al., Isolating and mapping of a human gene (RPD3L1) that if homologous to RPD3, a transcription factor inSaccharomyces cerevisiaeCytogenet. Cell. Genet. 1996, 78, 130-133.
Garcia Ramirez et al., “Role of the histone “tails” in the folding of oligonucleosomes depleted of histone H1”, J. Biol. Chem. 1992, 267, 19587.
Green et al. “When the products of oncogenes and anti-oncogenes meet”, Cell, 1989, 56, 1-3.
Hansen et al., “Retinoblastoma and the progression of tumor genetics”, Trends Genet, 1988, 4, 125-128.
Hayes et al., “Histones H2A/H2B inhibit the interaction of transcription factor IIIA with theXenopus borealissomatic 5S RNA gene in a nucleosome”, PNAS, 1992, 89, 1229-1233.
Hecht et al., “Histone H3 and H4 N-termini interact with SIR3 and SIR4 proteins: a molecular model for the formation of heterochromatin in yeast” , cell, 1995, 7, 583-592.
Johnson et al., “Genetic evidence for an interaction between SIR3 and histone H4 in the repression of the silent mating loci inSaccharomyces cerevisiae”, PNAS, 1990, 98, 6286.
Lee et al., “A positive role for histone acetylation in transcription factor access to nucleosomal DNA”, Cell, 1993, 72, 73-84.
Kijima et al., “ Trapoxim an Antitumor Cyclic Tetrapeptide, Is an Irreversible Inhibitor of mammalian Histone Daecetylase” J. Biol. Chem. 1993, 268, 22429-22435.
Kikuchi et al., “Multiplicity of histone deacetylase from calf thymus”, FEBS Lett. 1973, 29, 280-282.
Kleff et al. “Identification of a Gene Encoding a Yeast Histone H4 Acetyltransferase”, J. Bio. Chem. 1995, 270, 24674-24677.
Massa et al., “Synthesis and antimicrobial and cytotoxic activities of pyrrole-containing analogues of trichostatin A”, J. Med. Chem. 1990, 33, 2845-2849.
Mckenzie et al., “The centromere and promoter factor 1, CPFI, ofSaccharomyces cerevisiaemodulates gene activity through a family of factors including SPT21, RPD1 (SIN3), RPD3 and CCR4” Mol. Gen. Genet. 1993, 240, 374-386.
Megee et al., “Genetic analysis of histone H4: essential role of lysines subject to reversible acetylation”, Science, 1990, 247, 841-845.
Mori et al., “Synthesis of trichostatin a, a potent differentiation inducer of friend leukemic cells, and its antipode”, Tetrahedron, 1988, 44, 6013-6020.
Mowat et al. Mori et al., “Rearrangements of the cellular p53 gene in erythroleukaemic cells transformed by Friend virus”, Nature, 1985, 314, 633-636.
Nasmyth et al., “Both positive and negative regulators of HO transcription are required for mother-cell-specific mating-type switching in yeast”, cell, 1987, 48, 579-587.
Neer et al., “The ancient regulatory-protein family of WD-repeat proteins”, Nature, 1994, 371, 297-300.
Ngo et al., “Computational complexity protein structure prediction, and the llevinthal paradox” The Protein Folding Problem and Tertiary Structure Prediction, Eds. Merz, et al, Birkhauser et al., Boston , MA, 491-495, 1994.
Oliva et al., “Histone hyperacetylation can induce unfolding of the nucleosome core particle”, Nuc. Acid. Res. 1990, 18, 2739-2747.
Park et al., “Point mutations in the yeast histone H4 gene prevent silencing of the silent mating type locus HML”, Mol. Cell Biol., 1990, 10, 4932-4934.
Probst et al., “Human liver arylacetamide deacetylase” J. Biol. Chem., 1994, 269, 21650-21656.
Qian et al., “A retinoblastoma-binding protein related to a negative regulator of Ras in yeast”, Nature, 1993, 364, 648-652.
Rudinger, Characteristics of the amino acids as components of a peptide hormone sequence, Peptide Hormones, ed. Parsons, University Park Press, Baltimore, MD, 1-7, 1976.
Sanchez Del Pino et al., Properties of the Yeast Nuclear Histone Daecetylase, Biochem. J. 1994, 303, 723-729.
Strebhardt et al., “Additional member of the protein-tyrosine kinase family: The src-and Ick-related protooncogene c-tkl” PNAS, 1987, 84, 8778-8782.
Stillman et al., “Epistasis analysis of suppressor mutations that allow HO expression in the absence of the yeast SW15 transcriptional activator”, Genetics, 1994, 136, 781-788.
Tauton et al., “A Mammalian Histone Daecetylase related to the Yeast Transcriptional Regulator RPD3P” Science, 1996, 272, 408-411.
Thornton et al., “Protein Engineering; Editorial Overview” Current Opinion in Biotechnology, 1995, 6, 367-369.
Turner, “Decoding the nucleosome”
Hassig Christian A.
Jamison Timothy F.
Schreiber Stuart L.
Taunton Jack
Baker C. Hunter
Kumar Shailendra
President and Fellows of Harvard College
Wolf Greenfield & Sacks P.C.
LandOfFree
Histone deacetylases, and uses related thereto does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Histone deacetylases, and uses related thereto, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Histone deacetylases, and uses related thereto will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2761398