Histone deacetylase inhibitors

Organic compounds -- part of the class 532-570 series – Organic compounds – Hydroxamic acids – chalcogen analogs or salts thereof

Reexamination Certificate

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Details

C560S039000, C548S371700, C544S316000, C544S355000

Reexamination Certificate

active

07154002

ABSTRACT:
Histone deacetylase inhibitors and uses thereof are provided that have the general formulawhereinR1, R2, R3and R4are each independently selected from the group consisting of hydrogen, a substituted or unsubstituted straight chained C1-12alkyl, C2-12aminoalkyl or C2-12oxaalkyl, and a substituted and unsubstituted 3, 4, 5, 6, 7 or 8 membered ring, with the proviso that R3and R4are not both hydrogen;R5is selected from the group consisting of a carbonyl, a substituted or unsubstituted C1-3alkyl, a substituted or unsubstituted —C1-3alkyl-C(O), a substituted or unsubstituted —C(O)—C1-3alkyl, and a substituted or unsubstituted —C(O)C(O)C1-3alkyl;M is a substituent capable of complexing with a protein metal ion; andL is a substituent comprising a chain of 3–12 atoms connecting the M substituent to the carbon atom alpha to the L substituent.

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