Histone deacetylase inhibitors

Details Histone deacetylase inhibitors Histone deacetylase inhibitors

2006-12-26

2006-12-26

Davis, Brian (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Hydroxamic acids, chalcogen analogs or salts thereof

C560S039000, C548S371700, C544S316000, C544S355000

Reexamination Certificate

active

07154002

ABSTRACT:
Histone deacetylase inhibitors and uses thereof are provided that have the general formulawhereinR1, R2, R3and R4are each independently selected from the group consisting of hydrogen, a substituted or unsubstituted straight chained C1-12alkyl, C2-12aminoalkyl or C2-12oxaalkyl, and a substituted and unsubstituted 3, 4, 5, 6, 7 or 8 membered ring, with the proviso that R3and R4are not both hydrogen;R5is selected from the group consisting of a carbonyl, a substituted or unsubstituted C1-3alkyl, a substituted or unsubstituted —C1-3alkyl-C(O), a substituted or unsubstituted —C(O)—C1-3alkyl, and a substituted or unsubstituted —C(O)C(O)C1-3alkyl;M is a substituent capable of complexing with a protein metal ion; andL is a substituent comprising a chain of 3–12 atoms connecting the M substituent to the carbon atom alpha to the L substituent.

REFERENCES:
patent: 4482571 (1984-11-01), Abraham
patent: 4997815 (1991-03-01), Perrine et al.
patent: 5124342 (1992-06-01), Kerdesky et al.
patent: 5216004 (1993-06-01), Perrine
patent: 5439939 (1995-08-01), Perrine
patent: 5569675 (1996-10-01), Rephaeli et al.
patent: 5645852 (1997-07-01), Newmark
patent: 5656644 (1997-08-01), Adams et al.
patent: 5700826 (1997-12-01), Mjalli et al.
patent: 5858365 (1999-01-01), Faller
patent: 5922837 (1999-07-01), Meinke et al.
patent: 5939455 (1999-08-01), Rephaeli
patent: 5939456 (1999-08-01), Perrine
patent: 5993845 (1999-11-01), Geerts et al.
patent: 6011000 (2000-01-01), Perrine et al.
patent: 6030961 (2000-02-01), Nudelman et al.
patent: 6040342 (2000-03-01), Rephaeli et al.
patent: 6043277 (2000-03-01), Rephaeli et al.
patent: 6043389 (2000-03-01), Nudelman et al.
patent: 6068987 (2000-05-01), Dulski et al.
patent: 6071923 (2000-06-01), Nudelman et al.
patent: 6110697 (2000-08-01), Dulski et al.
patent: 6110955 (2000-08-01), Nudelman et al.
patent: 6110970 (2000-08-01), Nudelman et al.
patent: 6124495 (2000-09-01), Neiss et al.
patent: 6130248 (2000-10-01), Nudelman et al.
patent: 6174905 (2001-01-01), Suzuki et al.
patent: 6197743 (2001-03-01), Faller
patent: 6231880 (2001-05-01), Perrine
patent: 6235474 (2001-05-01), Feinberg
patent: 6239176 (2001-05-01), Nudelman et al.
patent: 6262116 (2001-07-01), Pandolfi et al.
patent: 6287790 (2001-09-01), Lelievre et al.
patent: 6329402 (2001-12-01), Kikuchi et al.
patent: 6335170 (2002-01-01), Orntoft
patent: 6372957 (2002-04-01), Olson
patent: 6376508 (2002-04-01), Li et al.
patent: 6387673 (2002-05-01), Evans et al.
patent: 6399568 (2002-06-01), Nishino et al.
patent: 6403555 (2002-06-01), Skov
patent: 6428983 (2002-08-01), Dulski et al.
patent: 6451334 (2002-09-01), Perrine et al.
patent: 6479629 (2002-11-01), Baldwin et al.
patent: 6495719 (2002-12-01), Lan-Hargest et al.
patent: 6506574 (2003-01-01), Rambhatla et al.
patent: 6511990 (2003-01-01), Breslow et al.
patent: 6512123 (2003-01-01), Grossmann et al.
patent: 6518012 (2003-02-01), Tomasi
patent: 6531472 (2003-03-01), Georges et al.
patent: 6538030 (2003-03-01), Chung et al.
patent: 6541661 (2003-04-01), Delorme et al.
patent: 6544957 (2003-04-01), Kern et al.
patent: 6548479 (2003-04-01), Skov
patent: 6552065 (2003-04-01), Remiszewski et al.
patent: 6562995 (2003-05-01), Lan-Hargest et al.
patent: 6599937 (2003-07-01), Neiss et al.
patent: 6632628 (2003-10-01), Olson et al.
patent: 6638530 (2003-10-01), Ishibashi et al.
patent: 6656905 (2003-12-01), Mori et al.
patent: 6673587 (2004-01-01), Evans
patent: 6689558 (2004-02-01), Case
patent: 6699902 (2004-03-01), Lan-Hargest et al.
patent: 6706686 (2004-03-01), Long et al.
patent: 6706762 (2004-03-01), Evans et al.
patent: 6720445 (2004-04-01), Lan-Hargest et al.
patent: 6777217 (2004-08-01), Schreiber et al.
patent: 6784173 (2004-08-01), Leser-Reiff et al.
patent: 6800638 (2004-10-01), Georges et al.
patent: 6809118 (2004-10-01), Chung
patent: 6825317 (2004-11-01), Nishino et al.
patent: 6828302 (2004-12-01), Skov
patent: 6831061 (2004-12-01), Lee et al.
patent: 6833384 (2004-12-01), Remiszewski et al.
patent: 6841565 (2005-01-01), Lucas et al.
patent: 6869953 (2005-03-01), Haag et al.
patent: 6875598 (2005-04-01), Buggy
patent: 6884597 (2005-04-01), Taya et al.
patent: 6888027 (2005-05-01), Watkins et al.
patent: 6897220 (2005-05-01), Delorme et al.
patent: 6905669 (2005-06-01), DiMartino
patent: 2001/0009922 (2001-07-01), Faller
patent: 2001/0012836 (2001-08-01), Hu et al.
patent: 2001/0027215 (2001-10-01), Perrine et al.
patent: 2001/0034367 (2001-10-01), Faller et al.
patent: 2002/0061860 (2002-05-01), Li et al.
patent: 2002/0065282 (2002-05-01), Georges et al.
patent: 2002/0076457 (2002-06-01), Aylward
patent: 2002/0103192 (2002-08-01), Curtin et al.
patent: 2002/0107404 (2002-08-01), Prien et al.
patent: 2002/0115177 (2002-08-01), Zhu
patent: 2002/0115826 (2002-08-01), Delorme et al.
patent: 2002/0119996 (2002-08-01), Lan-Hargest et al.
patent: 2002/0120099 (2002-08-01), Nishino et al.
patent: 2002/0132792 (2002-09-01), Prien et al.
patent: 2002/0137162 (2002-09-01), Li et al.
patent: 2002/0137775 (2002-09-01), Lan-Hargest et al.
patent: 2002/0143037 (2002-10-01), Lan-Hargest et al.
patent: 2002/0143052 (2002-10-01), Lan-Hargest et al.
patent: 2002/0143055 (2002-10-01), Lan-Hargest et al.
patent: 2002/0143196 (2002-10-01), Lan-Hargest et al.
patent: 2002/0161045 (2002-10-01), Lan-Hargest et al.
patent: 2002/0164752 (2002-11-01), Meyers
patent: 2002/0177594 (2002-11-01), Curtin et al.
patent: 2002/0183388 (2002-12-01), Gudas
patent: 2002/0183513 (2002-12-01), Grossmann et al.
patent: 2003/0013176 (2003-01-01), Pavletich et al.
patent: 2003/0013757 (2003-01-01), Laser-Reiff et al.
patent: 2003/0017454 (2003-01-01), Sukumar et al.
patent: 2003/0018062 (2003-01-01), Remiszawski et al.
patent: 2003/0059812 (2003-03-01), Richon et al.
patent: 2003/0078216 (2003-04-01), MacLeod et al.
patent: 2003/0078369 (2003-04-01), Meinke et al.
patent: 2003/0082666 (2003-05-01), Kammer et al.
patent: 2003/0082668 (2003-05-01), Tamai et al.
patent: 2003/0083521 (2003-05-01), Lan-Hargest et al.
patent: 2003/0124101 (2003-07-01), Gu et al.
patent: 2003/0125306 (2003-07-01), Lan-Hargest et al.
patent: 2003/0129724 (2003-07-01), Grozinger et al.
patent: 2003/0134865 (2003-07-01), Adcock et al.
patent: 2003/0139404 (2003-07-01), Haag et al.
patent: 2003/0143712 (2003-07-01), Verdin et al.
patent: 2003/0144276 (2003-07-01), Kikuchi et al.
patent: 2003/0144340 (2003-07-01), Long et al.
patent: 2003/0148970 (2003-08-01), Besterman et al.
patent: 2003/0149261 (2003-08-01), Schramm et al.
patent: 2003/0152557 (2003-08-01), Besterman et al.
patent: 2003/0154032 (2003-08-01), Pittman et al.
patent: 2003/0165903 (2003-09-01), Dang et al.
patent: 2003/0165956 (2003-09-01), Stevens et al.
patent: 2003/0171409 (2003-09-01), Lan-Hargest et al.
patent: 2003/0187027 (2003-10-01), Schreiber et al.
patent: 2003/0206946 (2003-11-01), Chung
patent: 2003/0207325 (2003-11-01), Guarente et al.
patent: 2003/0207791 (2003-11-01), Minucci et al.
patent: 2003/0212121 (2003-11-01), Kruger et al.
patent: 2003/0216345 (2003-11-01), Nakanishi et al.
patent: 2003/0219832 (2003-11-01), Klein et al.
patent: 2003/0224040 (2003-12-01), Baylin et al.
patent: 2003/0224473 (2003-12-01), McCafferty
patent: 2003/0235873 (2003-12-01), Krmer et al.
patent: 2004/0002447 (2004-01-01), Levine et al.
patent: 2004/0002506 (2004-01-01), Breslow et al.
patent: 2004/0005574 (2004-01-01), Guarente et al.
patent: 2004/0014647 (2004-01-01), Lee et al.
patent: 2004/0018522 (2004-01-01), Dangond et al.
patent: 2004/0018968 (2004-01-01), Sgouros et al.
patent: 2004/0023944 (2004-02-01), Lan-Hargest et al.
patent: 2004/0024067 (2004-02-01), Remiszewski et al.
patent: 2004/0028607 (2004-02-01), Verdin et al.
patent: 2004/0029903 (2004-02-01), Lan-Hargest et al.
patent: 2004/0029922 (2004-02-01), Lan-Hargest et al.
patent: 2004/0043470 (2004-03-01), Xiao
patent: 2004/0053820 (2004-03-01), Nakajima et al.
patent: 2004/0053960 (2004-03-01), Georges et al.
patent: 2004/0058868 (2004-03-01), James et al.
patent: 2004/0072735 (2004-04-01), Richon et al.
patent: 2004/0072770 (2004-04-01), Besterman

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