Histone deacetylase inhibitors

Details Histone deacetylase inhibitors Histone deacetylase inhibitors

2006-07-20

2010-11-30

Wang, Shengjun (Department: 1627)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

C514S567000, C514S568000

Reexamination Certificate

active

07842727

ABSTRACT:
Histone deacetylase is a metallo-enzyme with zinc at the active site. Compounds having a zinc-binding moiety, such as, for example, a hydroxamic acid group or a carboxylic acid group, can inhibit histone deacetylase. Histone deacetylase inhibition can repress gene expression, including expression of genes related to tumor suppression. Accordingly, inhibition of histone deacetylase can provide an alternate route for treating cancer, hematological disorders, e.g., hemoglobinopathies, genetic disorders, e.g. Huntington's disease and spinal muscular atrophy and genetic related metabolic disorders, e.g., cystic fibrosis and adrenoleukodystrophy.

REFERENCES:
patent: 2680755 (1954-06-01), Robeson et al.
patent: 2840586 (1958-06-01), Inhoffen
patent: 3479396 (1969-11-01), Buu-Hoi et al.
patent: 3551574 (1970-12-01), Frohberger et al.
patent: 3624127 (1971-11-01), Shaw et al.
patent: 3674884 (1972-07-01), Moritani et al.
patent: 3687955 (1972-08-01), Cerbati et al.
patent: 3755604 (1973-08-01), Gallo
patent: 3781314 (1973-12-01), Bollag et al.
patent: 3875232 (1975-04-01), Magee
patent: 3886278 (1975-05-01), Gallo
patent: 3909353 (1975-09-01), Tsuchida et al.
patent: 3978100 (1976-08-01), Fujita et al.
patent: 3984440 (1976-10-01), Bollag et al.
patent: 4011339 (1977-03-01), Galantay et al.
patent: 4024182 (1977-05-01), Kathawala
patent: 4044149 (1977-08-01), Fields et al.
patent: 4048332 (1977-09-01), Adams et al.
patent: 4061656 (1977-12-01), Klaus et al.
patent: 4081476 (1978-03-01), Anderson et al.
patent: 4113858 (1978-09-01), Hashim
patent: 4116975 (1978-09-01), Klaus et al.
patent: 4127722 (1978-11-01), Lafon
patent: 4127723 (1978-11-01), Yankee
patent: 4130653 (1978-12-01), Giroux et al.
patent: 4171318 (1979-10-01), Chan et al.
patent: 4188338 (1980-02-01), Bruins et al.
patent: 4193931 (1980-03-01), Loeliger
patent: 4211783 (1980-07-01), Shepherd
patent: 4258057 (1981-03-01), Bartmann et al.
patent: 4288253 (1981-09-01), Venable
patent: 4309357 (1982-01-01), Chiusoli et al.
patent: 4309407 (1982-01-01), Lautenschläger et al.
patent: 4335054 (1982-06-01), Blaser et al.
patent: 4355168 (1982-10-01), Chiusoli et al.
patent: 4371614 (1983-02-01), Anderson et al.
patent: 4388459 (1983-06-01), Shepherd
patent: 4439443 (1984-03-01), Giroux
patent: 4440940 (1984-04-01), Shepherd
patent: 4447627 (1984-05-01), Näf et al.
patent: 4472430 (1984-09-01), Loev et al.
patent: 4504494 (1985-03-01), Grollier et al.
patent: 4505930 (1985-03-01), Loev et al.
patent: 4513005 (1985-04-01), Baker et al.
patent: 4534979 (1985-08-01), Loev et al.
patent: 4545984 (1985-10-01), Möller et al.
patent: 4564476 (1986-01-01), Ho
patent: 4604407 (1986-08-01), Haslanger et al.
patent: 4605669 (1986-08-01), Summers, Jr.
patent: 4607053 (1986-08-01), Karanewsky et al.
patent: 4608390 (1986-08-01), Summers, Jr.
patent: 4619945 (1986-10-01), Loev et al.
patent: 4621099 (1986-11-01), Loev et al.
patent: 4623661 (1986-11-01), Summers, Jr.
patent: 4638011 (1987-01-01), Das
patent: 4663336 (1987-05-01), Nakane et al.
patent: 4699920 (1987-10-01), Skuballa et al.
patent: 4709076 (1987-11-01), Bombardelli et al.
patent: 4722939 (1988-02-01), Loev et al.
patent: 4731382 (1988-03-01), Zusi et al.
patent: 4753934 (1988-06-01), Nickl et al.
patent: 4791133 (1988-12-01), Djuric et al.
patent: 4820828 (1989-04-01), Demers et al.
patent: 4833257 (1989-05-01), Pettit et al.
patent: 4950467 (1990-08-01), Phalangas et al.
patent: 4965283 (1990-10-01), Klessing et al.
patent: 4966721 (1990-10-01), Farng et al.
patent: 4981865 (1991-01-01), Belliotti et al.
patent: 4985436 (1991-01-01), Pettit
patent: 5010189 (1991-04-01), Herold et al.
patent: 5028629 (1991-07-01), Hite et al.
patent: 5037813 (1991-08-01), Black et al.
patent: 5064860 (1991-11-01), Mueller et al.
patent: 5075330 (1991-12-01), Belliotti et al.
patent: 5075482 (1991-12-01), Seltzer et al.
patent: 5084214 (1992-01-01), Kita et al.
patent: 5089524 (1992-02-01), Collins et al.
patent: 5091569 (1992-02-01), Matsumoto et al.
patent: 5093532 (1992-03-01), Baasner et al.
patent: 5112846 (1992-05-01), Belliotti et al.
patent: 5141959 (1992-08-01), Carroll et al.
patent: 5196147 (1993-03-01), Taketani et al.
patent: 5235068 (1993-08-01), Minai et al.
patent: 5244922 (1993-09-01), Burzynski
patent: 5246955 (1993-09-01), Skibo et al.
patent: 5264424 (1993-11-01), Della Valle et al.
patent: 5272180 (1993-12-01), Hashimoto et al.
patent: 5320833 (1994-06-01), Deckers et al.
patent: 5369108 (1994-11-01), Breslow et al.
patent: 5385942 (1995-01-01), Abe et al.
patent: 5420160 (1995-05-01), Gayer et al.
patent: 5451689 (1995-09-01), Matsumoto et al.
patent: 5475022 (1995-12-01), Chandraratna
patent: 5481029 (1996-01-01), Braun et al.
patent: 5486540 (1996-01-01), Andrews
patent: 5523495 (1996-06-01), Oda et al.
patent: 5525629 (1996-06-01), Criramin et al.
patent: 5541155 (1996-07-01), Leone-Bay et al.
patent: 5547988 (1996-08-01), Yu et al.
patent: 5601699 (1997-02-01), Degnan et al.
patent: 5602135 (1997-02-01), Chandraratna
patent: 5607978 (1997-03-01), Woodward et al.
patent: 5608062 (1997-03-01), Döller et al.
patent: 5643949 (1997-07-01), Van Scott et al.
patent: 5672746 (1997-09-01), Nau et al.
patent: 5677320 (1997-10-01), Chandraratna
patent: 5688819 (1997-11-01), Woodward et al.
patent: 5696162 (1997-12-01), Chandraratna
patent: 5705167 (1998-01-01), Bernardon et al.
patent: 5710178 (1998-01-01), Samid
patent: 5747537 (1998-05-01), Gordon et al.
patent: 5753704 (1998-05-01), Lindner et al.
patent: 5795914 (1998-08-01), Konno et al.
patent: 5804601 (1998-09-01), Kato et al.
patent: 5466718 (1998-11-01), Nakatsu et al.
patent: 5859052 (1999-01-01), Nugent et al.
patent: 5872152 (1999-02-01), Brown et al.
patent: 5877329 (1999-03-01), Chen et al.
patent: 5883124 (1999-03-01), Samid
patent: 5891737 (1999-04-01), Baindur et al.
patent: 5908868 (1999-06-01), Buck et al.
patent: 5910508 (1999-06-01), Thoreau et al.
patent: 5910606 (1999-06-01), Foricher et al.
patent: 5925644 (1999-07-01), Jakobi et al.
patent: 5932606 (1999-08-01), Isaacs et al.
patent: 5935773 (1999-08-01), Hagemann et al.
patent: 5965719 (1999-10-01), Hindsgaul
patent: 5968979 (1999-10-01), Brusilow
patent: 5977074 (1999-11-01), Cordell et al.
patent: 5981580 (1999-11-01), Nugent et al.
patent: 5986131 (1999-11-01), Klaus et al.
patent: 5998654 (1999-12-01), Boehm et al.
patent: 6001877 (1999-12-01), Konno et al.
patent: 6004988 (1999-12-01), Amberg et al.
patent: 6030993 (2000-02-01), Jew et al.
patent: 6037367 (2000-03-01), Christensen, IV et al.
patent: 6043389 (2000-03-01), Nudelman et al.
patent: 6046237 (2000-04-01), Berge et al.
patent: 6057369 (2000-05-01), Groneberg et al.
patent: 6060510 (2000-05-01), Brusilow
patent: 6068987 (2000-05-01), Dulski et al.
patent: 6071923 (2000-06-01), Nudelman et al.
patent: 6083984 (2000-07-01), Brusilow
patent: 6110697 (2000-08-01), Dulski et al.
patent: 6110955 (2000-08-01), Nudelman et al.
patent: 6110970 (2000-08-01), Nudelman et al.
patent: 6118001 (2000-09-01), Owen et al.
patent: 6124495 (2000-09-01), Neiss et al.
patent: 6133296 (2000-10-01), Lieb et al.
patent: 6147224 (2000-11-01), Vuligonda et al.
patent: 6150567 (2000-11-01), Sugawa et al.
patent: 6187966 (2001-02-01), Sugawa et al.
patent: 6201123 (2001-03-01), Daikai et al.
patent: 6235717 (2001-05-01), Leban et al.
patent: 6255342 (2001-07-01), Lieb et al.
patent: 6262278 (2001-07-01), Jacobsen et al.
patent: 6350892 (2002-02-01), Banville et al.
patent: 6376508 (2002-04-01), Li et al.
patent: 6451067 (2002-09-01), Lagrange et al.
patent: 6451334 (2002-09-01), Perrine
patent: 6458168 (2002-10-01), Lagrange et al.
patent: RE37947 (2002-12-01), Bernardon et al.
patent: 6495719 (2002-12-01), Lan-Hargest et al.
patent: 6511990 (2003-01-01), Breslow et al.
patent: 6636090 (2003-10-01), Andrean et al.
patent: 6656937 (2003-12-01), Germann et al.
patent: 7312247 (2007-12-01), Lan-Hargest et al.
patent: 7314953 (2008-01-01), Wiech et al.
patent: 2001/0028364 (2001-10-01), Fredell et al.
patent: 2002/0143037 (2002-10-01), Lan-Hargest et al.
patent: 2003/0083521 (2003-05-01), Lan-Hargest et

Affiliated with

Also associated with

Rating

Histone deacetylase inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Histone deacetylase inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Histone deacetylase inhibitors will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4158277